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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Barrenetxea, Gorka |
| Description | Country affiliation: Spain Author Affiliation: Barrenetxea G ( Quiron Bilbao, Assisted Reproduction Center, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Ribera Botica Vieja 23, 48014 Bilbao, Spain. gbarrenetxea.bil@quiron.es) |
| Abstract | Although Creutzfeldt-Jakob disease (CJD) was first identified in 1920, prevention of transmission raised particular concern all over the world when a new variant of the disease was first described in 1996. There is good evidence of iatrogenic transmission of this new variant among human beings through blood, blood components, tissues and growth hormone. Furthermore, four cases of iatrogenic transmission of CJD through fertility treatment with human pituitary-derived gonadotrophins have been reported. It is important to distinguish the categories of infectivity and categories of risk, which require consideration not only of the level of infectivity of a given tissue or fluid, but also the amount of tissue/fluid to which a person is exposed, the duration of exposure and the route by which infection is transmitted. The potential presence and infectivity of prion proteins in human urinary gonadotrophin preparations is a matter of debate. Differences in the sensitivity of bioassay methods are of paramount importance when considering the infectivity of a tissue. Some new methods might detect small amounts of agent in some tissues currently thought to be free of infectivity. No cases of human prion disease due to the use of urinary gonadotrophins have been recognized to date. However, the detection of prions in the urine of experimental animals and in some urine-based preparations, and the young age of fertility drug recipients, require the application of the precautionary principle to urinary preparations. |
| File Format | HTM / HTML |
| ISSN | 03012115 |
| Issue Number | 2 |
| Volume Number | 165 |
| e-ISSN | 18727654 |
| Journal | European Journal of Obstetrics & Gynecology and Reproductive Biology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Creutzfeldt-jakob Syndrome Transmission Iatrogenic Disease Prevention & Control Prion Diseases Adult Animals Blood Transfusion Adverse Effects Female Fertility Agents Gonadotropins Humans Prions Urine Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Reproductive Medicine Obstetrics and Gynecology |
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