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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdellah, Mohamad Sayed Elsaman, Ali Mahmoud Mohamad Mostafa |
| Description | Country affiliation: Egypt Author Affiliation: Abdellah MS ( Women's Health Center, Department of Obstetrics & Gynaecology, Faculty of Medicine, Assiut University, P.O. Box 1, 71116 Assiut, Egypt. msayed21@yahoo.com) |
| Abstract | OBJECTIVE: The aim of the trial was to assess the safety and efficacy of tricholoroacetic acid for the treatment of dysfunctional uterine bleeding using topical versus intrauterine instillation. STUDY DESIGN: In a pilot prospective randomized clinical trial, seventy women were randomly allocated to one of two groups. In Group I, the patients were subjected to intrauterine instillation of 95% tricholoroacetic acid. Group II underwent dilatation and curettage before topical application of 95% tricholoroacetic acid. RESULTS: The groups were similar regarding baseline clinical characteristics. There was a satisfactory clinical reduction of menstrual flow (amenorrhea, hypomenorrhea and eumenorrhea) at a rate of 97.1% (Group I) and 85.7% (Group II) at 6 months. A significant increase was observed in the mean haemoglobin value at 3 and 6 months in both treatment groups (P<0.05). Group I showed a significant increase in haemoglobin level compared to Group II (P<0.05) and a significant reduction of the endometrial thickness compared to Group II (2.21 ± 0.41 versus 3.03 ± 3.37). CONCLUSION: Trichloroacetic acid use for treating dysfunctional uterine bleeding seems to be efficient and safe, especially in women who do not require conception. Trichloroacetic acid intrauterine instillation is associated with longer duration of reduced menstrual bleeding than topical application. |
| File Format | HTM / HTML |
| ISSN | 03012115 |
| Issue Number | 2 |
| Volume Number | 165 |
| e-ISSN | 18727654 |
| Journal | European Journal of Obstetrics & Gynecology and Reproductive Biology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Metrorrhagia Drug Therapy Trichloroacetic Acid Administration & Dosage Administration, Topical Adult Dilatation And Curettage Endometrium Drug Effects Female Hemoglobins Analysis Humans Surgery Pilot Projects Treatment Outcome Uterus Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Reproductive Medicine Obstetrics and Gynecology |
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