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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Woopen, H. Sehouli, J. Pietzner, K. Darb-Esfahani, S. Braicu, E. I. Fotopoulou, C. |
| Description | Country affiliation: Germany Author Affiliation: Woopen H ( European Competence Center for Ovarian Cancer (EKZE), Department of Gynecology, Charité-University Medicine of Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.) |
| Abstract | OBJECTIVE: Small cell ovarian cancer of the hypercalcemic type (OSCCHT) is a very rare and highly aggressive disease which mainly affects young women, while optimal treatment guidelines have not yet been defined. The objective of this work is to present our experience with four OSCCHT patients. STUDY DESIGN: We evaluated the surgical course and clinical outcome of all OSCCHT patients treated in the European Competence Center for Ovarian Cancer, Charité, University Medicine of Berlin. Pathology was reviewed by specialized gynecological pathologists of our center. RESULTS: Four OSCCHT patients were identified between 2008 and 2011 (median age: 24.5 years; range: 18-29) out of 845 ovarian cancer patients being operated on within this timeframe. Two patients were diagnosed at a very early tumor stage (FIGO Ia), one in FIGO IIb, and one patient presented with advanced stage disease FIGO IIIc. Treatment of choice was surgery followed by adjuvant platinum-based chemotherapy. In all patients the uterus was preserved and also the contralateral ovary in three out of the four patients. Within a median follow-up time of 22 months (range: 8-47) only the FIGO IIIC-patient relapsed twice and died 15 months after initial diagnosis. The other three patients are all alive and with no signs of relapse at 8, 29 and 47 months after initial diagnosis. CONCLUSION: OSCCHT is a rare tumor entity which usually affects young women with hopes of childbearing. The clinical course varies widely and although it is associated with an overall dismal prognosis, fertility-sparing surgery followed by platinum-based adjuvant chemotherapy may be considered in early stages of the disease. |
| File Format | HTM / HTML |
| ISSN | 03012115 |
| Issue Number | 2 |
| Volume Number | 165 |
| e-ISSN | 18727654 |
| Journal | European Journal of Obstetrics & Gynecology and Reproductive Biology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Carcinoma, Small Cell Therapy Hypercalcemia Neoplasms, Glandular And Epithelial Ovarian Neoplasms Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Carboplatin Administration & Dosage Surgery Chemotherapy, Adjuvant Cisplatin Fatal Outcome Female Humans Case Reports Journal Article |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Reproductive Medicine Obstetrics and Gynecology |
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