NDLI: Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lam, Tram Kim Ruczinski, Ingo Helzlsouer, Kathy J. Shugart, Yin Yao Caulfield, Laura E. Alberg, Anthony J.
Description	Country affiliation: United States Author Affiliation: Lam TK ( Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.)
Abstract	BACKGROUND: Due predominantly to cigarette smoking, lung cancer is the leading cancer-related cause of death worldwide. Cruciferous vegetables may reduce lung cancer risk. The association between intake of cruciferous vegetables and lung cancer risk was investigated in the CLUE II study, a community-based cohort established in 1989. METHODS: We matched 274 incident cases of lung cancer diagnosed from 1990 to 2005 to 1,089 cancer-free controls on age, sex, and cigarette smoking. Dietary information was collected at baseline. Multivariable odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using conditional logistic regression. RESULTS: Intake of cruciferous vegetables was inversely associated with lung cancer risk (highest-versus-lowest fourth: OR (Q4vsQ1), 0. 57; 95% CI, 0.38-0.85; P-trend = 0.01). The inverse associations held true for former smokers (OR(Q4vsQ1), 0.49; 95% CI, 0.27-0.92; P-trend = 0.05) and current smokers (OR(Q4vsQ1), 0.52; 95% CI, 0.29-0.95; P-trend = 0.02). CONCLUSIONS: After carefully controlling for cigarette smoking, higher intake of cruciferous vegetable was associated with lower risk of lung cancer. IMPACT: The observed inverse association coupled with accumulating evidence suggests that intake of cruciferous vegetables is inversely associated with lung cancer risk, and this association seems to hold true beyond the confounding effects of cigarette smoking.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-10-0475
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	10
Volume Number	19
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2010-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Lung Neoplasms Epidemiology Smoking Vegetables Case-control Studies Cohort Studies Diet Prevention & Control Prospective Studies Risk Assessment Risk Factors Adverse Effects Smoking Cessation Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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