NDLI: Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer.

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Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pio, Ruben Garcia, Javier Corrales, Leticia Ajona, Daniel Fleischhacker, Michael Pajares, Maria J. Cardenal, Felipe Seijo, Luis Zulueta, Javier J. Nadal, Ernest Witt, Christian Lozano, Maria D. Schmidt, Bernd Montuenga, Luis M.
Description	Country affiliation: Spain Author Affiliation: Pio R ( Division of Oncology, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain. rpio@unav.es)
Abstract	BACKGROUND: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use of molecular biomarkers may enhance the sensitivity of cytologic examination in the detection of lung cancer. METHODS: Complement factor H, a protein secreted by lung cancer cells, was quantified in a series of bronchoalveolar lavage supernatants from lung cancer patients and patients with nonmalignant respiratory diseases. Albumin, total protein content, and hemoglobin were also analyzed. Results were validated in independent sets of bronchoalveolar lavage and sputum supernatants. RESULTS: There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. The sensitivity and specificity of the factor H test was 82% and 77%, respectively. These results were validated in an independent set of patients with nearly identical results. Furthermore, 70% and 45% of bronchoalveolar lavage fluids from central and peripheral tumors, respectively, reported as cytologically negative, were classified as positive using this marker. Finally, the test was evaluated in a series of sputum supernatants from lung cancer patients and controls. The sensitivity and specificity of the factor H test in this series was 80% and 88%, respectively. CONCLUSION: Factor H is elevated in bronchoalveolar lavage and sputum from lung cancer patients. IMPACT: Measurement of molecular biomarkers, such as complement factor H, may be used in the future as an adjunct to cytology in the diagnosis of malignant pulmonary diseases.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	10
Volume Number	19
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2010-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Tumor Markers, Biological Metabolism Bronchoalveolar Lavage Fluid Immunology Complement Factor H Lung Neoplasms Sputum Bronchoscopy Cohort Studies Diagnosis Pathology Sensitivity And Specificity Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer.

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