NDLI: Prospective study of human papillomavirus (HPV) types, HPV persistence, and risk of squamous cell carcinoma of the cervix.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sundström, Karin Eloranta, Sandra Sparén, Pär Arnheim Dahlström, Lisen Gunnell, Anthony Lindgren, Anders Palmgren, Juni Ploner, Alexander Sanjeevi, Carani B. Melbye, Mads Dillner, Joakim Adami, Hans-Olov Ylitalo, Nathalie
Description	Country affiliation: Sweden Author Affiliation: Sundström K ( Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. karin.sundstrom@ki.se)
Abstract	BACKGROUND: The link between squamous cell cervical carcinoma and human papillomavirus (HPV) 16/18 is well established, but the magnitude of the risk association is uncertain and the importance of other high-risk HPV (HRHPV) types is unclear. METHODS: In two prospective nested case-control series among women participating in cytologic screening in Sweden, we collected 2,772 cervical smears from 515 women with cancer in situ (CIS), 315 with invasive squamous cell carcinoma (SCC), and individually matched controls. All smears were tested for HPV with PCR assays, and the median follow-up until diagnosis was 5 to 7 years. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (95% CI). RESULTS: The presence of HPV16/18 in the first smear was associated with 8.5-fold (95% CI, 5.3-13.7) and 18.6-fold (95% CI, 9.0-38.9) increased risks of CIS and SCC, respectively, compared with women negative for HPV. Infection with other HRHPV types in the first smear was also associated with significantly increased risks for both CIS and SCC. Persistence of HPV16 infection conferred a RR of 18.5 (95% CI, 6.5-52.9) for CIS and 19.5 (95% CI, 4.7-81.7) for SCC. The HPV16/18 attributable risk proportion was estimated at 30% to 50% for CIS, and 41% to 47% for SCC. Other HRHPV types also conferred significant proportions. CONCLUSIONS: Our large population-based study provides quantification of risks for different HPV types and prospective evidence that non-16/18 HRHPV types increase the risk for future cervical cancer. IMPACT: This study gives further insights into cervical cancer risk stratification with implications for HPV-based prevention strategies.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
DOI	10.1158/1055-9965.EPI-10-0424
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	10
Volume Number	19
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2010-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Carcinoma In Situ Pathology Carcinoma, Squamous Cell Virology Human Papillomavirus 16 Isolation & Purification Human Papillomavirus 18 Papillomavirus Infections Uterine Cervical Neoplasms Adolescent Etiology Case-control Studies Classification Prospective Studies Risk Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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Prospective study of HPV16 viral load and risk of in situ and invasive squamous cervical cancer.

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