NDLI: Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.

Please wait, while we are loading the content...

High-throughput simultaneous analysis of five urinary metabolites of areca nut and tobacco alkaloids by isotope-dilution liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction.

Adherence to a breast cancer screening program and its predictors in underserved women in southern Brazil.

Carbamazepine but not valproate induces CYP2A6 activity in smokers with mental illness.

Serum Platelet Factor 4 is an Independent Predictor of Survival and Venous Thromboembolism in Patients with Pancreatic Adenocarcinoma

Lipophilic statin use and risk of breast cancer subtypes.

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.

Reproductive factors, hormone use, and risk for lung cancer in postmenopausal women, the Nurses' Health Study.

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study.

Oral contraceptive use and breast cancer: a prospective study of young women.

Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women.

Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer.

Effect of long-term storage in TRIzol on microarray-based gene expression profiling.

Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk

Method of detection and breast cancer survival disparities in Hispanic women.

Alcohol-folate interactions in the risk of oral cancer in women: a prospective cohort study.

Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking.

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development.

Do steroid hormones play a role in the etiology of glioma?

Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation.

Five-year and lifetime risk of breast cancer among U.S. subpopulations: implications for magnetic resonance imaging screening.

Integrating tools for breast cancer risk assessment, risk reduction, and early detection.

Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.

Indoor tanning and risk of melanoma: a case-control study in a highly exposed population - letter.

Year: 2010 Volume: 19 Issue: 9

Year: 2010 Volume: 19 Issue: 8

Year: 2010 Volume: 19 Issue: 7

Year: 2010 Volume: 19 Issue: 6

Year: 2010 Volume: 19 Issue: 5

Year: 2010 Volume: 19 Issue: 4

Year: 2010 Volume: 19 Issue: 3

Year: 2010 Volume: 19 Issue: 2

Year: 2010 Volume: 19 Issue: 1

Year: 2009 Volume: 18

Year: 2008 Volume: 17

Year: 2007 Volume: 16

Year: 2006 Volume: 15

Year: 2005 Volume: 14

Year: 2004 Volume: 13

Year: 2003 Volume: 12

Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, Yu Jin, Yan Guo, Xia Bai, Xin Chen, Taoyang Wang, Jinbing Qian, Gengsun Groopman, John D. Gu, Jianren Li, Jinjun Tu, Hong
Description	Country affiliation: China Author Affiliation: Zhu Y ( Shanghai Medical College, Fudan University, Shanghai, China.)
Abstract	BACKGROUND: Mutations in the hepatitis B virus (HBV) genome may influence the activity of liver disease. The aim of this study was to identify new viral variations associated with hepatocellular carcinoma (HCC). METHODS: We carried out a comparison study on the complete sequence of HBV isolated from 20 HCC and 35 non-HCC patients in Qidong, China, an area with a high incidence of HCC. We compared the HBV sequences in a consecutive series of plasma samples from four HCC cases before and after the occurrence of HCC. In addition, we selected four mutations in the HBV core (C) gene to verify their relationships to HCC in an independent set of 103 HCC cases and 103 sex- and age-matched non-HCC controls. RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with HCC. In the validation study, A2159G, A2189C, and G2203W showed consistent associations with HCC by univariate analysis. Multivariate analysis showed that A2189C and G2203W were independent risk factors for HCC. The odds ratios (95% confidence interval) were 3.99 (1.61-9.92) and 9.70 (1.17-80.58), respectively, for A2189C and G2203W. CONCLUSIONS: These results implicate A2189C and G2203W as new predictive markers for HCC. IMPACT: The complete genome analysis of HBV provided pilot data for the identification of novel mutations that could serve as markers for HCC.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	10
Volume Number	19
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2010-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Carcinoma, Hepatocellular Virology Hepatitis B Virus Genetics Liver Neoplasms Blood Case-control Studies Dna, Viral Genome, Viral Genotype Longitudinal Studies Point Mutation Reproducibility Of Results Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hepatitis C virus Genotype 1a core gene nucleotide patterns associated with hepatocellular carcinoma risk.

Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China.

Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma.

Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study.

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma.

Hepatitis B virus mutations associated with in situ expression of hepatitis B core antigen, viral load and prognosis in chronic hepatitis B patients.

Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.

Hepatitis B and hepatocellular carcinoma.

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.

Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.

Similar Documents

Hepatitis C virus Genotype 1a core gene nucleotide patterns associated with hepatocellular carcinoma risk.

Prospective evaluation of hepatitis B 1762(T)/1764(A) mutations on hepatocellular carcinoma development in Shanghai, China.

Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma.

Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study.

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma.

Hepatitis B virus mutations associated with in situ expression of hepatitis B core antigen, viral load and prognosis in chronic hepatitis B patients.

Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.

Hepatitis B and hepatocellular carcinoma.

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.

Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.