NDLI: Determination of lansoprazole enantiomers in dog plasma by column-switching liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.

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Determination of lansoprazole enantiomers in dog plasma by column-switching liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.

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Determination of lansoprazole enantiomers in dog plasma by column-switching liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Hao Sun, Yantong Meng, Xiangjun Yang, Bo Wang, Jian Yang, Yan Gu, Jingkai
Description	Author Affiliation: Wang H ( School of Life Sciences, Jilin University, Changchun, P.R. China.); Sun Y ( Research Center for Drug Metabolism, Jilin University, Changchun, P.R. China.); Meng X ( School of Pharmaceutical Sciences, Jilin University, Changchun, P.R. China.); Yang B ( School of Life Sciences, Jilin University, Changchun, P.R. China.); Wang J ( School of Life Sciences, Jilin University, Changchun, P.R. China.); Yang Y ( Southeast Environmental Research Center, Florida International University, North Miami, FL, USA.); Gu J ( School of Life Sciences, Jilin University, Changchun, P.R. China.)
Abstract	Lansoprazole, a selective proton pump inhibitor, has a chiral benzimidazole sulfoxide structure and is used for the treatment of gastric acid hypersecretory related diseases. To investigate its stereoselective pharmacokinetics, a column-switching liquid chromatography with tandem mass spectrometry method was developed for the determination of lansoprazole enantiomers in dog plasma using (+)-pantoprazole as an internal standard. After a simple protein precipitation procedure with acetonitrile, matrix components left behind after sample preparation were further eliminated from the sample by reversed-phase chromatography on a C18 column. The fluent was fed to a chiral column for the separation of lansoprazole enantiomers. Baseline separation of lansoprazole enantiomers was achieved on a Chiralcel OZ-RH column using acetonitrile/0.1% formic acid in water (35:65, v/v) as the mobile phase at 40°C. The linearity of the calibration curves ranged from 3 to 800 ng/mL for each enantiomer. Intra- and inter-day precisions ranged from 2.1 to 7.3% with an accuracy of ±1.7% for (+)-lansoprazole, and from 1.6 to 6.9% with an accuracy of ±3.5% for (-)-lansoprazole, respectively. The validated method was successfully applied for the stereoselective pharmacokinetic study of lansoprazole in beagle dog after intravenous infusion.
File Format	HTM / HTML
ISSN	16159306
Issue Number	17
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Lansoprazole Blood Pharmacokinetics Animals Calibration Chromatography, High Pressure Liquid Methods Dogs Equipment Design Gastric Acid Chemistry Limit Of Detection Plasma Quality Control Reproducibility Of Results Stereoisomerism Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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