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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chu, Chu Zhang, Shidi Tong, Shengqiang Li, Xingnuo Li, Qingyong Yan, Jizhong |
| Description | Author Affiliation: Chu C ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.); Zhang S ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.); Tong S ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.); Li X ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.); Li Q ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.); Yan J ( College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.) |
| Abstract | In this work, a simple and efficient protocol for the rapid separation of two pairs of isomeric monoterpenes from Paeoniae Alba Radix was developed by combining macroporous resin and elution-extrusion counter-current chromatography. The crude extract was firstly subjected to a D101 macroporous resin column eluted with water and a series of different concentrations of ethanol. Then, effluents of 30 and 95% ethanol were collected as sample 1 and sample 2 for further counter-current chromatography purification. Finally, a pair of isomers, 96 mg of compound 1 and 48 mg of compound 2 with purities of 91.1 and 96.2%, respectively, was isolated from 200 mg of sample 1. The other pair of isomers, 14 mg of compound 3 and 8 mg of compound 4 with purities of 93.6 and 88.9%, respectively, was isolated from 48 mg of sample 2. Their purities were analyzed by high-performance liquid chromatography, and their chemical structures were identified by mass spectrometry and (1) H NMR spectroscopy. Compared to a normal counter-current chromatography separation, the separation time and solvent consumption of elution-extrusion counter-current chromatography were reduced while the resolutions were still good. The established protocol is promising for the separation of natural products with great disparity of content in herbal medicines. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 17 |
| Volume Number | 38 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-09-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Chromatography Methods Monoterpenes Chemistry Paeonia Bridged Compounds Chromatography, High Pressure Liquid Countercurrent Distribution Ethanol Glucosides Glycosides Magnetic Resonance Spectroscopy Mass Spectrometry Plant Preparations Solvents Ultrasonography Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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