NDLI: Enantioselective determination of (R)- and (S)-lansoprazole in human plasma by chiral liquid chromatography with mass spectrometry and its application to a stereoselective pharmacokinetic study.

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Enantioselective determination of (R)- and (S)-lansoprazole in human plasma by chiral liquid chromatography with mass spectrometry and its application to a stereoselective pharmacokinetic study.

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Enantioselective determination of (R)- and (S)-lansoprazole in human plasma by chiral liquid chromatography with mass spectrometry and its application to a stereoselective pharmacokinetic study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sun, Luning Cao, Yang Jiao, Huiwen Fang, Yunqian Yang, Zhicheng Bian, Mingliang Zhang, Hongwen Gong, Xiaojian Wang, Yongqing
Description	Country affiliation: China Author Affiliation: Sun L ( Research Division of Clinical Pharmacology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.); Cao Y ( Department of Gastroenterology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.); Jiao H ( Department of Pharmacology, China Pharmaceutical University, Nanjing, China.); Fang Y ( Department of Pharmacology, China Pharmaceutical University, Nanjing, China.); Yang Z ( Department of Pharmacology, China Pharmaceutical University, Nanjing, China.); Bian M ( Research Division of Clinical Pharmacology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.); Zhang H ( Research Division of Clinical Pharmacology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.); Gong X ( Department of Pharmacology, China Pharmaceutical University, Nanjing, China.); Wang Y ( Research Division of Clinical Pharmacology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.)
Abstract	A simple and enantioselective method was developed and validated for the simultaneous determination of (R)- and (S)-lansoprazole in human plasma by chiral liquid chromatography with tandem mass spectrometry. Lansoprazole enantiomers and internal standard (esomeprazole) were extracted from plasma using acetonitrile as protein precipitating agent. Baseline chiral separation was achieved within 9.0 min on a Chiralpak IC column (150 mm × 4.6 mm, 5 µm) with the column temperature of 30°C. The mobile phase consisted of 10 mM ammonium acetate solution containing 0.05% acetic acid/acetonitrile (50:50, v/v). The mass spectrometric analysis was performed using a QTrap 5500 mass spectrometer coupled with an electrospray ionization source in positive ion mode. The multiple reactions monitoring transitions of m/z 370.1â252.1 and 346.1â198.1 were used to quantify lansoprazole enantiomers and esomeprazole, respectively. For each enantiomer, no apparent matrix effect was found, the calibration curve was linear over 5.00-3000 ng/mL, the intra- and inter-day precisions were below 10.0%, and the accuracy was -3.8 to 3.3%. Analytes were stable during the study. No chiral inversion was observed during sample storage, preparation procedure and analysis. The method was applied to the stereoselective pharmacokinetic studies in human after intravenous administration of dexlansoprazole or racemic lansoprazole.
File Format	HTM / HTML
ISSN	16159306
Issue Number	21
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-11-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Anti-ulcer Agents Blood Chromatography, Liquid Methods Lansoprazole Mass Spectrometry Chemistry Pharmacokinetics Humans Stereoisomerism Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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