NDLI: Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica.

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Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica.

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Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lv, Mengying Chen, Jiaqing Gao, Yiqiao Sun, Jianbo Zhang, Qianqian Zhang, Mohan Xu, Fengguo Zhang, Zunjian
Description	Country affiliation: China Author Affiliation: Lv M ( Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, China.); Chen J ( State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China.); Gao Y ( Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, China.); Sun J ( State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China.); Zhang Q ( Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, China.); Zhang M ( State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China.); Xu F ( Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.); Zhang Z ( Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, China.)
Abstract	To better understand different traditional uses of the stems (known as Mahuang) and roots (known as Mahuanggen) of Ephedra sinica, their chemical difference should be investigated. In this study, an ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry untargeted metabolomics approach was established to reveal global chemical difference between Mahuang and Mahuanggen. Clear separation was observed in scores plots of principal component analysis and orthogonal partial least squares-discriminant analysis. Twenty two chemical markers responsible for such separation were screened out and unambiguously/tentatively characterized. Then chemical markers of pharmacologically important ephedrine and pseudoephedrine were absolutely quantified using liquid chromatography coupled with tandem mass spectrometry under multiple reaction monitoring mode. The results showed that Mahuang was rich in ephedrine-type alkaloids, while Mahuanggen was rich in macrocyclic spermine alkaloids. Additionally, different types of flavan-3-ols and flavones exist in Mahuang and Mahuanggen extracts. This research facilitates a better understanding of different traditional uses of Mahuang and Mahuanggen and provides references for chemical analysis of other medicinal plants.
File Format	HTM / HTML
ISSN	16159306
Issue Number	19
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-10-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Chromatography, High Pressure Liquid Methods Drugs, Chinese Herbal Chemistry Ephedra Sinica Mass Spectrometry Metabolomics Ephedrine Analysis Humans Medicine, Chinese Traditional Statistics & Numerical Data Plant Roots Plant Stems Pseudoephedrine Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica.

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Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica.