NDLI: In vitro anticancer screening of South African plants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fouche, G. Cragg, G. M. Pillay, P. Kolesnikova, N. Maharaj, V. J. Senabe, J.
Spatial Coverage	South Africa
Description	Country affiliation: South Africa Author Affiliation: Fouche G ( Biosciences, Council for Scientific and Industrial Research, PO Box 395, Pretoria, Gauteng 0001, South Africa. gfouche@csir.co.za)
Abstract	AIM OF THE STUDY: The purpose of the present study is to evaluate South African plants for their anticancer activity. MATERIALS AND METHODS: Plant species were collected throughout South Africa and voucher specimens were deposited and identified at the South African National Biodiversity Institute. Plant extracts were prepared and screened for in vitro anticancer activity against a panel of three human cell lines (breast MCF7, renal TK10 and melanoma UACC62) at the CSIR. Plant extracts that exhibited anticancer activity against these three human cell lines were screened by the NCI against sixty human cancer cell lines organized into sub-panels representing leukaemia, melanoma, cancer of the lung, colon, kidney, ovary, central nervous system, breast and prostate. RESULTS: A total of 7500 plant extracts were screened for in vitro anticancer activity against breast MCF7, renal TK10 and melanoma UACC62 human cell lines between the period 1999 and 2006. Hits were classified into four categories based on their total growth inhibition of the cell lines. A hit rate of 5.9% was obtained for extracts which showed moderate activity and these were screened by the NCI against a panel of sixty human cancer cell lines. The extracts of plant species with limited published information for their anticancer properties were subjected to bioassay-guided fractionation and the active constituents isolated and identified. The largest number of plant specimens in this study was from the family Asteraceae, which is rich in sesquiterpene lactones. CONCLUSIONS: Although the extracts of the plants were randomly selected, 68% of these plant species which were hits in the screening programme are reported to be used medicinally. Based on our data, it appears that unrelated medicinal use of the source plants may serve as an initial guide to selection of plants for anticancer screening.
File Format	HTM / HTML
ISSN	03788741
Issue Number	3
Volume Number	119
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2008-10-28
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antineoplastic Agents, Phytogenic Pharmacology Plants, Medicinal Chemistry Isolation & Purification Cell Line, Tumor Drug Screening Assays, Antitumor Humans Plant Extracts Solvents South Africa Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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