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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pedersen, Mikael E. Szewczyk, Bernadeta Stachowicz, Katarzyna Wieronska, Joanna Andersen, Jacob Stafford, Gary I. Van Staden, Johannes Pilc, Andrzej Jäger, Anna K. |
| Description | Country affiliation: Denmark Author Affiliation: Pedersen ME ( Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen O, Denmark.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 3 |
| Volume Number | 119 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-10-28 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Antidepressive Agents Pharmacology Medicine, African Traditional Plants, Medicinal Chemistry Alkaloids Isolation & Purification Animals Binding, Competitive Drug Effects Carbohydrate Sequence Citalopram Metabolism Dopamine Plasma Membrane Transport Proteins Antagonists & Inhibitors Hindlimb Suspension Psychology Male Mice Mice, Inbred C57bl Molecular Sequence Data Motor Activity Norepinephrine Plasma Membrane Transport Proteins Plant Extracts Therapeutic Use Rats Serotonin Plasma Membrane Transport Proteins Serotonin Uptake Inhibitors Swimming Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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