NDLI: Selection methodology with scoring system: application to Mexican plants producing podophyllotoxin related lignans.

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Selection methodology with scoring system: application to Mexican plants producing podophyllotoxin related lignans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lautié, E. Quintero, R. Fliniaux, M-A Villarreal, M-L
Spatial Coverage	Mexico
Description	Country affiliation: Mexico Author Affiliation: Lautié E ( Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos 62209, Mexico.)
Abstract	As most anticancer drugs are derived from natural sources, the screening of local medicinal flora should be considered a primary step in the search for new sources for antineoplastic agents. In Mexico, more than 6000 medicinal plant species are used for the treatment of various diseases, including cancer. A multifactorial plant selection method, employing various criteria was designed and applied in order to select alternative sources of podophyllotoxin lignan analogues. For each criterion (chemotaxonomy, traditional medical uses and published scientific data), an arbitrary score system was ascribed to the species and the sum of these enabled us to compare potential candidates. The resulting selected plants were tested for cytotoxic activity and the compounds responsible for this activity were evaluated by liquid chromatography-mass spectroscopy (LC-MS). Around 50 species from the Mexican flora were initially considered. From these, six species were selected by referring to the results from the scoring system and these were then collected. Three extracts were evaluated as being highly cytotoxic against three different cancer cell lines. Finally, podophyllotoxin-like lignans could be identified by observing the fragmentation pattern on mass spectra, obtained from the LC-MS in two species: Linum scabrellum and Hyptis suaveolens.
File Format	HTM / HTML
ISSN	03788741
Issue Number	3
Volume Number	120
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2008-12-08
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antineoplastic Agents, Phytogenic Pharmacology Drug Screening Assays, Antitumor Methods Lignans Neoplasms Drug Therapy Plants, Medicinal Chemistry Podophyllotoxin Cell Line, Tumor Drug Effects Chromatography, High Pressure Liquid Humans Isolation & Purification Mexico Phytotherapy Plant Extracts Research Design Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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