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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kwon, Seung-Hwan Kim, Min-Jung Ma, Shi-Xun You, In-Jee Hwang, Ji-Young Oh, Ji-Hwan Kim, Sun-Yeou Kim, Hyoung-Chun Lee, Seok-Yong Jang, Choon-Gon |
| Description | Author Affiliation: Kwon SH ( Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Eucommia ulmoides Oliv. Bark. (EUE), has commonly been used to fortify the muscles and lungs, lower blood pressure, prevent miscarriage, improve the tone of liver and kidneys, and promote longevity the traditional tonic medicines of Korea, China, and Japan. AIM OF THE STUDY: In this study, we investigated that the neuroprotective activities and possible mechanisms of EUE aqueous extract in hydrogen peroxide (H(2)O(2))-induced neuronal cell death in human SH-SY5Y neuroblastoma cells. MATERIAL AND METHOD: We examined the effects of EUE against H(2)O(2)-induced cytotoxicity, DNA condensation, the production of reactive oxygen species (ROS), loss of mitochondria membrane potential (MMP), the proteolysis of cleaved poly-ADP-ribose polymerase (PARP), and the expression of Bcl-2, Bcl-xL, cleaved caspase-3, and release of cytochrome c. Moreover, we attempted to determine whether EUE suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase 1/2 (ERK 1/2), and phosphoinositide 3-kinase (PI3K)/Akt. RESULTS: Pretreatment with EUE increased cell viability and inhibited cytotoxicity and DNA condensation. EUE also attenuated the increase in ROS production and MMP reduction. Western blot data revealed that EUE inhibited H(2)O(2)-induced up- or down-regulation of cleaved PARP, cleaved caspase-3, Bcl-2, and Bcl-xL. The EUE inhibited release of cytochrome c from mitochondria to the cytosol, and significantly attenuated H(2)O(2)-induced phosphorylation of JNK, p38 MAPK, ERK 1/2, and PI3K/Akt. CONCLUSION: The potent neuroprotective capacity of EUE, shown in these experiments, may potentially be applied in the prevention or treatment of neurodegenerative diseases such as Alzheimer's disease (AD). |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 142 |
| Journal | Journal of Ethnopharmacology |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-13 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Antioxidants Pharmacology Cell Death Drug Effects Eucommiaceae Neurodegenerative Diseases Neurons Neuroprotective Agents Plant Extracts Therapeutic Use Biological Transport Caspase 3 Metabolism Cell Line Cell Survival Cytochromes c Cytosol Dna Humans Hydrogen Peroxide Jnk Mitogen-activated Protein Kinases Membrane Potential, Mitochondrial Mitochondria Mitogen-activated Protein Kinase 3 Mitogen-activated Protein Kinases Drug Therapy Genetics Phosphorylation Phytotherapy Poly(adp-ribose) Polymerases Proteolysis Proto-oncogene Proteins C-akt Proto-oncogene Proteins C-bcl-2 Reactive Oxygen Species P38 Mitogen-activated Protein Kinases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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