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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Saravana Babu, Chidambaram Sathiya, Sekar Anbarasi, Chandrasekaran Prathyusha, Nettam Ramakrishnan, Ganapathy Kalaivani, Periyathambi Jyothi Priya, Raju Selvarajan Kesavanarayanan, Krishnamoorthy Verammal Mahadevan, Murugappapillai Thanikachalam, Sadagopan |
| Description | Country affiliation: India Author Affiliation: Saravana Babu C ( Centre for Toxicology and Developmental Research (CEFT), Sri Ramachandra University, Chennai 600 116, TN, India.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Present study was undertaken to demonstrate the mode of anti-diabetic action of a polyherbal Siddha Medicine, Madhumega chooranam (MMC). MATERIALS AND METHODS: MMC was fractionated into phenolic (PMMC) and non-phenolic (NPMMC) portions in order to identify bioactive fraction. Study was performed in type II diabetic rats. Role of PMMC and NPMMC on liver glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucokinase and glycogen content were determined. Their role on superoxide dismutase, reduced glutathione and lipid peroxidation were investigated. In addition, their effects on GLUT4 and PPARγ gene expression were studied. Pancreas and liver histopathology was studied using hematoxylin and eosin stain. RESULTS: PMMC improved carbohydrate metabolism by decreasing glucose-6-phosphatase and fructose-1,6-bisphosphatase and increasing glucokinase and glycogen contents in diabetic rats liver. It alleviated oxidative stress by increasing superoxide dismutase, glutathione and decreasing lipid peroxidation content. PMMC up-regulated liver GLUT4 and PPARγ mRNA expression in comparison to the vehicle or NPMMC rats. CONCLUSION: Madhumega chooranam mediates its anti-diabetic action through the inhibition of gluconeogenesis and activation of glycolytic pathways in type II diabetic rats. Increased GLUT4 and PPARγ expressions provide additional information on its glucose uptake/sensitising and hypolipidemic potential. Phenolic components of MMC were found to be the bioactive principles. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 142 |
| Journal | Journal of Ethnopharmacology |
| e-ISSN | 18727573 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-13 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Carbohydrate Metabolism Drug Effects Diabetes Mellitus, Experimental Drug Therapy Hypoglycemic Agents Therapeutic Use Oxidative Stress Phytotherapy Plant Extracts Polyphenols Animals Antioxidants Pharmacology Genetics Metabolism Female Fructose-bisphosphatase Gene Expression Glucokinase Gluconeogenesis Glucose Transporter Type 4 Glucose-6-phosphatase Glutathione Glycogen Glycolysis Lipid Peroxidation Liver Medicine, Ayurvedic Ppar Gamma Rna, Messenger Rats Rats, Sprague-dawley Superoxide Dismutase Up-regulation Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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