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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Subbarayan, Pochi R. Sarkar, Malancha Nagaraja Rao, Shamaladevi Philip, Sakhi Kumar, Pradeep Altman, Norman Reis, Isildinha Ahmed, Mansoor Ardalan, Bach Lokeshwar, Bal L. |
| Description | Country affiliation: United States Author Affiliation: Subbarayan PR ( Department of Medicine, University of Miami Miller School of Medicine, Miami FL-33136, USA. spochi@med.miami.edu) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Achyranthes aspera (Family Amaranthacea) is used for cancer therapy by ayurvedic medical practitioners in India. However, due to the non formal nature of its use, there are no systematic studies validating its medicinal properties. Thus, it's utility as an anti cancer agent remains anecdotal. Earlier, we demonstrated A. aspera to exhibit time and dose-dependent preferential cytotoxicity to cultured human pancreatic cancer cells. In this report we validate in vivo anti tumor properties of A. aspera. MATERIALS AND METHODS: The in vivo anti tumor activity of leaf extract (LE) was tested by intraperitoneal (IP) injections into athymic mice harboring human pancreatic tumor subcutaneous xenograft. Toxicity was monitored by recording changes in behavioral, histological, hematological and body weight parameters. RESULTS: Dosing LE to athymic mice by I.P. injection for 32 days showed no adverse reactions in treated mice. Compared to the control set, IP administration of LE to tumor bearing mice significantly reduced both tumor weight and volume. Gene expression analysis using Real time PCR methods revealed that LE significantly induced caspase-3 mRNA (p<0.001) and suppressed expression of the pro survival kinase Akt-1 (p<0.05). TUNEL assay and immunohistochemistry confirmed apoptosis induction by activation of caspase-3 and inhibiting Akt phosphorylation in treated sets. These results are in agreement with RT PCR data. CONCLUSION: Taken together, these data suggest A. aspera to have potent anti cancer property. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 142 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-13 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Achyranthes Antineoplastic Agents, Phytogenic Therapeutic Use Apoptosis Drug Effects Pancreatic Neoplasms Drug Therapy Phytotherapy Plant Extracts Animals Pharmacology Caspase 3 Genetics Metabolism Gene Expression Humans Injections, Intraperitoneal Medicine, Ayurvedic Mice Mice, Nude Phosphorylation Plant Leaves Proto-oncogene Proteins C-akt Rna, Messenger Xenograft Model Antitumor Assays Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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