NDLI: Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Santana, Danielle G. Santos, Cliomar A. Santos, Alan D. C. Nogueira, Paulo C. L. Thomazzi, Sara M. Estevam, Charles S. Antoniolli, Angelo R. Camargo, Enilton A.
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Santana DG ( Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, 49100-000 SE, Brazil.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Caesalpinia pyramidalis Tul. (Fabaceae) is a plant found in the Northeast of Brazil that is popularly used to treat inflammation. Acute pancreatitis (AP) is an inflammatory disease for which abdominal pain is a relevant symptom. As there is no specific therapy for AP, we investigated the effect of the ethanol extract from the inner bark of C. pyramidalis (EECp) on the AP induced by common bile duct obstruction (CBDO) in rats. MATERIAL AND METHODS: AP was induced in male Wistar rats (200-250 g, n=6-8) through laparotomy and subsequent CBDO. Animals were euthanized after 6 (G6h) or 24 h (G24h) of induction. In the G6h protocol, animals were pretreated with EECp (100-400 mg/kg, p.o.) or vehicle (Tween 80; 0.2%) 1h before CBDO or sham surgery. For the G24h protocol, rats were pretreated with EECp (400mg/kg, 1h before CBDO or 1 h before and 12 h after CBDO) or vehicle. The following parameters were measured: inflammatory/oxidative (myeloperoxidase activity and malondialdehyde formation in the pancreas and lung, leukocyte counts in the blood and serum nitrate/nitrite), enzymatic (serum amylase and lipase levels) and nociceptive (abdominal hyperalgesia). RESULTS: Induction of AP by CBDO significantly increased all the parameters evaluated in both G6h and G24h protocols when compared with the respective sham group. In the G6h protocol, the EECp pretreatment (400 mg/kg) significantly reduced all these parameters, besides completely inhibiting abdominal hyperalgesia. The same profile of reduction was observed from two administrations of EECp in the G24h protocol, while one single dose of EECp was able to significantly reduce pancreatic MDA, serum lipase levels, leukocyte counts in the blood and abdominal hyperalgesia without affecting the other parameters in the G24h protocol. Furthermore, rutin was found in the EECp. CONCLUSIONS: Our results demonstrated that EECp decreases inflammation, lipoperoxidation and hyperalgesia in CBDO-induced AP, making it of interest in future approaches to treat this condition.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	142
Journal	Journal of Ethnopharmacology
e-ISSN	18727573
Language	English
Publisher	Elsevier
Publisher Date	2012-07-13
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Abdominal Pain Drug Therapy Caesalpinia Chemistry Hyperalgesia Inflammation Pancreas Drug Effects Pancreatitis Phytotherapy Etiology Metabolism Acute Disease Amylases Blood Analgesics Pharmacology Therapeutic Use Animals Anti-inflammatory Agents Brazil Cholestasis Common Bile Duct Leukocyte Count Leukocytes Lipase Lung Male Malondialdehyde Nitrates Nitrites Complications Peroxidase Plant Bark Plant Extracts Rats Rats, Wistar Rutin Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gastroprotective activity of the ethanol extract from the inner bark of Caesalpinia pyramidalis in rats.

Possible mechanisms of action of Caesalpinia pyramidalis against ethanol-induced gastric damage.

Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae).

Effects of the bradykinin antagonist, HOE 140, in experimental acute pancreatitis.

Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models.

Nitrites and nitrates in the human diet: Carcinogens or beneficial hypotensive agents?

Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome.

Protective effects of daphnetin on sodium taurocholateinduced severe acute pancreatitis in rats.

Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.

Similar Documents

Gastroprotective activity of the ethanol extract from the inner bark of Caesalpinia pyramidalis in rats.

Possible mechanisms of action of Caesalpinia pyramidalis against ethanol-induced gastric damage.

Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae).

Effects of the bradykinin antagonist, HOE 140, in experimental acute pancreatitis.

Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models.

Nitrites and nitrates in the human diet: Carcinogens or beneficial hypotensive agents?

Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome.

Protective effects of daphnetin on sodium taurocholate­induced severe acute pancreatitis in rats.

Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.

Protective effects of daphnetin on sodium taurocholateinduced severe acute pancreatitis in rats.