NDLI: Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bredella, Miriam A. Utz, Andrea L. Torriani, Martin Thomas, Bijoy Schoenfeld, David A. Miller, Karen K.
Description	Country affiliation: United States Author Affiliation: Bredella MA ( Department of Radiology, Massachusetts General Hospita, Boston, MA 02114, USA. mbredella@partners.org)
Abstract	Visceral adiposity is a strong determinant of growth hormone (GH) secretion, and states of GH deficiency are associated with increased visceral adiposity and decreased lean body mass. The purpose of our study was to determine the sensitivity and specificity of different methods of assessing body composition [anthropometry, dual-energy X-ray absorptiometry (DXA), and computed tomography (CT)] to predict GH deficiency in premenopausal women and threshold values for each technique to predict GH deficiency, using receiver operator characteristic (ROC) curve analysis. We studied a group of 45 healthy lean, overweight, and obese premenopausal women who underwent anthropometric measurements (body mass index, waist and hip circumferences, skin fold thickness), DXA, CT, and a GH-releasing hormone-arginine stimulation test. ROC curve analysis was used to determine cutoff values for each method to identify GH deficiency. Visceral adiposity measured by CT showed the highest sensitivity and specificity for identifying subjects with GH deficiency with a cutoff of >9,962 mm(2) [area under the curve (AUC), 0.95; sensitivity, 100%; specificity, 77.8%; P = 0.0001]. Largest waist circumference showed high sensitivity and specificity with a cutoff of >101.7 cm (AUC, 0.89; sensitivity, 88.9%; specificity, 75%; P = 0.0001). When the ROC curves of visceral fat measured by CT and largest waist circumference were compared, the difference between the two methods was not statistically significant (P = 0.36). Our study showed that the largest waist circumference predicts the presence of GH deficiency in healthy premenopausal women with high sensitivity and specificity and nearly as well as CT measurement of visceral adiposity. It can be used to identify women in whom GH deficiency is likely and therefore in whom formal GH stimulation testing might be indicated.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.90998.2008
Journal	Journal of Applied Physiology
Issue Number	2
Volume Number	106
Language	English
Publisher	American Physiological Society
Publisher Date	2009-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Absorptiometry, Photon Adiposity Anthropometry Endocrine System Diseases Diagnosis Human Growth Hormone Deficiency Intra-abdominal Fat Obesity Complications Tomography, X-ray Computed Body Mass Index Diagnostic Techniques, Endocrine Blood Etiology Physiopathology Predictive Value Of Tests Premenopause Roc Curve Reproducibility Of Results Sensitivity And Specificity Skinfold Thickness Waist Circumference Comparative Study Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis

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