NDLI: Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training.

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Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yan, Bei Jiye, A. Wang, Guangji Lu, Huali Huang, Xiaoping Liu, Yi Zha, Weibin Hao, Haiping Zhang, Ying Liu, Linsheng Gu, Shenghua Huang, Qing Zheng, Yuanting Sun, Jianguo
Description	Author Affiliation: Yan B ( Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, People's Republic of China.)
Abstract	Strength-endurance type of sport can lead to modification of human beings' physiological status. The present study aimed to investigate the alteration of metabolic phenotype or biochemical compositions in professional athletes induced by long-term training by means of a novel systematic tool, metabolomics. Resting venous blood samples of junior and senior male rowers were obtained before and after 1-wk and 2-wk training. Venous blood from healthy male volunteers as control was also sampled at rest. Endogenous metabolites in serum were profiled by GC/TOF-MS and multivariate statistical technique, i.e., principal component analysis (PCA), and partial least squares projection to latent structures and discriminant analysis (PLS-DA) were used to process the data. Significant metabolomic difference was observed between the professional athletes and control subjects. Long-term strength and endurance training induced distinct separation between athletes of different exercise seniority, and training stage-related trajectory of the two groups of athletes was clearly shown along with training time. However, most of these variations were not observed by common biochemical parameters, such as hemoglobin, testosterone, and creatine kinase. The identified metabolites contributing to the classification included alanine, lactate, beta-d-methylglucopyranoside, pyroglutamic acid, cysteine, glutamic acid, citric acid, free fatty acids, valine, glutamine, phenylalanine, tyrosine, and so on, which were involved in glucose metabolism, oxidative stress, energy metabolism, lipid metabolism, amino acid metabolism. These findings suggest that metabolomics is a promising and potential tool to profile serum of professional athletes, make a deep insight into physiological states, and clarify the disorders induced by strength-endurance physical exercise.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	2
Volume Number	106
Language	English
Publisher	American Physiological Society
Publisher Date	2009-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Biological Markers Blood Metabolomics Muscle Contraction Muscle, Skeletal Metabolism Physical Endurance Adaptation, Physiological Amino Acids Case-control Studies Creatine Kinase Discriminant Analysis Energy Metabolism Gas Chromatography-mass Spectrometry Glucose Hemoglobins Least-squares Analysis Lipid Metabolism Oxidative Stress Phenotype Principal Component Analysis Testosterone Time Factors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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