NDLI: Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps.

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Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peters, Anju T. Kato, Atsushi Zhang, Ning Conley, David B. Suh, Lydia Tancowny, Brian Carter, Derek Carr, Tara Radtke, Michael Hulse, Kathryn E. Seshadri, Sudarshan Chandra, Rakesh Grammer, Leslie C. Harris, Kathleen E. Kern, Robert Schleimer, Robert P.
Description	Country affiliation: United States Author Affiliation: Peters AT ( Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.)
Abstract	BACKGROUND: IL-6 activates T(H)17 cells and regulates the response of B lymphocytes and regulatory T cells. The IL-6 receptor and the membrane protein, glycoprotein 130 (gp130), form an active signaling complex that signals through signal transducer and activator of transcription 3 (STAT3) and other signaling molecules. Both the IL-6 receptor (IL-6R) and gp130 can be found in soluble forms that regulate the pathway. OBJECTIVE: We measured IL-6 signaling components and IL-17 in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), CRS without nasal polyps (CRSsNP), and controls to assess the IL-6 pathway in CRS. METHODS: IL-6, soluble IL-6R, soluble gp130 (sgp130), and IL-17 were measured in sinus tissue extracts and in nasal lavage fluid by either cytokine bead array or ELISA. phosphoSTAT3 (p-STAT3) was determined by Western blot and by immunohistochemistry. RESULTS: IL-6 protein was significantly (P < .001) increased in CRSwNP compared with CRSsNP and controls. Soluble IL-6R was also increased in nasal polyp compared with control tissue (P < .01). Despite elevated IL-6 and sIL-6R, IL-17A, E, and F were undetectable in the sinus tissue from most of the patients with CRS and controls. p-STAT3 levels were reduced in the polyp tissue, possibly indicating reduced activity of IL-6 in the tissue. sgp130 was elevated in CRSwNP compared with CRSsNP and controls. CONCLUSION: p-STAT3 levels are decreased in CRSwNP despite increased levels of IL-6 and sIL-6R and are associated with the absence of an IL-17 response. This may be a response to elevated levels of sgp130, a known inhibitor of IL-6 signaling. These results indicate that IL-6 and its signaling pathway may be altered in CRSwNP.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2009.10.072
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	125
Language	English
Publisher	Elsevier
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Interleukin-6 Immunology Nasal Polyps Rhinitis Signal Transduction Sinusitis Blotting, Western Chronic Disease Cytokine Receptor Gp130 Metabolism Enzyme-linked Immunosorbent Assay Immunohistochemistry Interleukin-17 Receptors, Interleukin-6 Stat3 Transcription Factor Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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