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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stephansen, Karen Mattebjerg, Maria Wattjes, Jasper Milisavljevic, Ana Jessen, Flemming Qvortrup, Klaus Goycoolea, Francisco M. Chronakis, Ioannis S. |
| Description | Author Affiliation: Stephansen K ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark. Electronic address: kaste@food.dtu.dk.); Mattebjerg M ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark.); Wattjes J ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark); Milisavljevic A ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark.); Jessen F ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark.); Qvortrup K ( University of Copenhagen, Department of Biomedical Sciences, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.); Goycoolea FM ( IBBP, Westfälische Wilhelms-Universität Münster Schlossgarten 3, 48149 - Münster, Germany. Electronic address: goycoole@uni-muenster.de.); Chronakis IS ( Technical University of Denmark, DTU-Food, Søltofts Plads 227, DK-2800 Kgs Lyngby, Denmark. Electronic address: ioach@food.dtu.dk.) |
| Abstract | Macrostructures based on natural polymers are subject to large attention, as the application range is wide within the food and pharmaceutical industries. In this study we present nanocomplexes (NCXs) made from electrostatic self-assembly between negatively charged alginate and positively charged fish sarcoplasmic proteins (FSP), prepared by bulk mixing. A concentration screening revealed that there was a range of alginate and FSP concentrations where stable NCXs with similar properties were formed, rather than two exact concentrations. The size of the NCXs was 293 ± 3 nm, and the zeta potential was -42 ± 0.3 mV. The NCXs were stable in water, gastric buffer, intestinal buffer and HEPES buffered glycose, and at all pH values from 2 to 9 except pH 3, where they aggregated. When proteolytic enzymes were present in the buffer, the NCXs were degraded. Only at high concentrations the NCXs caused a decreased viability in HeLa and U2OS cell lines. The simple processing procedure and the high stability of the NCXs, makes them excellent candidates for use in the food and pharmaceutical industry. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 76 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Alginates Chemistry Fish Proteins Nanocomposites Buffers Cell Line Drug Carriers Drug Delivery Systems Glucuronic Acid Hexuronic Acids Humans Hydrogen-ion Concentration Toxicity Ultrastructure Particle Size Proteolysis Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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