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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Amirian, Jhaleh Linh, Nguyen Thuy Ba Min, Young Ki Lee, Byong-Taek |
| Description | Author Affiliation: Amirian J ( Department of regenerative medicine, College of Medicine, Soonchunhyang University366-1, Ssangyong-dong, Cheonan-City, ChungCheongNam-Do 330-090, Republic of Korea.); Linh NT ( Department of regenerative medicine, College of Medicine, Soonchunhyang University366-1, Ssangyong-dong, Cheonan-City, ChungCheongNam-Do 330-090, Republic of Korea); Min YK ( Department of Physiology, College of Medicine, Soonchunhyang University366-1, Ssangyong-dong, Cheonan-City, ChungCheongNam-Do 330-090, Republic of Korea); Lee BT ( Department of regenerative medicine, College of Medicine, Soonchunhyang University366-1, Ssangyong-dong, Cheonan-City, ChungCheongNam-Do 330-090, Republic of Korea) |
| Abstract | A composite scaffold of gelatin (Gel)-pectin (Pec)-biphasic calcium phosphate (BCP) was fabricated for the successful delivery of growth factors. Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) were coated on the Gel-Pec-BCP surface to investigate of effect of them on bone healing. Surface morphology was investigated by scanning electron microscopy, and BCP dispersion in the hydrogel scaffolds was measured by energy dispersive X-ray spectroscopy. The results obtained from Fourier transform infrared spectroscopy showed that BMP-2 and VEGF were successfully coated on Gel-Pec-BCP hydrogel scaffolds. MC3T3-E1 preosteoblasts were cultivated on the scaffolds to investigate the effect of BMP-2 and VEGF on cell viability and proliferation. VEGF and BMP-2 loaded on Gel-Pec-BCP scaffold facilitated increased cell spreading and proliferation compared to Gel-Pec-BCP scaffolds. In vivo, bone formation was examined using rat models. Bone formation was observed in Gel-Pec-BCP/BMP-2 and Gel-Pec-BCP/VEGF scaffolds within 4 weeks, and was greatest with Gel-Pec-BCP/BMP-2 scaffolds. In vitro and in vivo results suggest that Gel-Pec-BCP/BMP-2 and Gel-Pec-BCP/VEGF scaffolds could enhance bone regeneration. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 76 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Bone Morphogenetic Protein 2 Pharmacology Calcium Phosphates Chemistry Gelatin Osteogenesis Drug Effects Pectins Tissue Scaffolds Vascular Endothelial Growth Factor A Animals Bone Regeneration Cell Proliferation Cell Survival Mice Porosity Rats Skull Cytology Physiology X-ray Microtomography Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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