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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zan, Xinyi Cui, Fengjie Li, Yunhong Yang, Yan Wu, Di Sun, Wenjing Ping, Lifeng |
| Description | Author Affiliation: Zan X ( School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P.R. China); Cui F ( School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P.R. China. Electronic address: fengjiecui@163.com.); Li Y ( School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P.R. China.); Yang Y ( National Engineering Research Center of Edible Fungi, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, P.R. China. Electronic address: yangyan@saas.sh.cn.); Wu D ( National Engineering Research Center of Edible Fungi, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, P.R. China.); Sun W ( School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P.R. China.); Ping L ( Institute of Quality and Standard for Agroproducts, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, P.R. China. Electronic address: lfping2005@gmail.com.) |
| Abstract | HEG-5 is a novel polysaccharide-protein purified from the fermented mycelia of Hericium erinaceus CZ-2. The present study aims to investigate the effects of HEG-5 on proliferation, cell cycle and apoptosis of human gastric cancer cells SGC-7901. Here, we first uncover that HEG-5 significantly inhibited the proliferation and colony formation of SGC-7901 cells by promoting apoptosis and cell cycle arrest at S phase. RT-PCR and Western blot analysis suggested that HEG-5 could decrease the expressions of Bcl2, PI3K and AKT1, while increase the expressions of Caspase-8, Caspase-3, p53, CDK4, Bax and Bad. These findings indicated that the Caspase-8/-3-dependent, p53-dependent mitochondrial-mediated and PI3k/Akt signaling pathways involved in the molecular events of HEG-5 induced apoptosis and cell cycle arrest. Thus, our study provides in vitro evidence that HEG-5 may be taken as a potential candidate for treating gastric cancer. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 76 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Apoptosis Drug Effects Basidiomycota Metabolism Cell Cycle Checkpoints Complex Mixtures Chemistry Pharmacology Fungal Polysaccharides Fungal Proteins Genetics Cell Line Cell Proliferation Gene Expression Profiling Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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