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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bansal, Divya Gulbake, Arvind Tiwari, Jyoti Jain, Sanjay K. |
| Description | Author Affiliation: Bansal D ( Pharmaceutics Research Laboratory, Shri Ram Institute of Technology, Faculty of Pharmacy, Jabalpur, MP, India. Electronic address: drdivyabansal1126@gmail.com.); Gulbake A ( Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, India.); Tiwari J ( Department of Medicine, Bundelkhand Medical College, Sagar, MP, India.); Jain SK ( Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, India.) |
| Abstract | BACKGROUND: Folic Acid conjugated liposomes encapsulating Oxaliplatin (L-OHP) were entrapped in alginate beads and further coated with Eudragit-S-100 for effective delivery to colon tumors. METHODS: Liposomes were prepared by cast film method and folic acid was coupled on the surface of liposomes. They were further entrapped in alginate beads which were Eudragit coated for degradation in the colonic region. The prepared beads were characterized for shape and surface morphology, percentage entrapment efficiency and drug release studies. The in vitro drug release was investigated using a USP dissolution paddle type apparatus in different simulated gastrointestinal fluids. In vivo studies of the beads containing free drug, folic acid coupled and uncoupled liposomes bearing L-OHP was administered orally at the dose of 10mg L-OHP/kg body weight to tumor bearing NUDE/SCID mice. RESULTS: γ-Scintigraphic study showed that Eudragit coated alginate beads entered into the colon of Balb/c mice between 4.20 and 4.50h after oral administration. In vivo data showed that folic acid coupled liposomes entrapped in alginate beads delivered 2.82 ± 0.58 and 21.52 ± 2.76 µg L-OHP/g tissues in the colon and tumor after 12h, reflecting its targeting potential to colon and tumor. CONCLUSION: The results clearly demonstrate that Eudragit coated calcium alginate beads bearing folic acid coupled liposome can be used as a prospective carrier for drug delivery to colon specific tumor. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 82 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Alginates Chemistry Antineoplastic Agents Administration & Dosage Drug Carriers Drug Delivery Systems Liposomes Microspheres Animals Pharmacokinetics Cell Line, Tumor Coated Materials, Biocompatible Colorectal Neoplasms Drug Therapy Disease Models, Animal Drug Compounding Drug Liberation Glucuronic Acid Hexuronic Acids Humans Hydrogen-ion Concentration Male Mice Organoplatinum Compounds Particle Size Polymethacrylic Acids Tissue Distribution Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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