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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Al-Kahtani, Ahmed A. Sherigara, B. S. |
| Description | Author Affiliation: Al-Kahtani AA ( Department of Chemistry, Faculty of Education and Science, Albayda'a University, Rada'a 6539551, Yemen. Electronic address: ahmeda.ahmed7012@yahoo.com.); Sherigara BS ( Department of Industrial Chemistry, Kuvempu University, Shankaraghatta 577451, Karnataka, India.) |
| Abstract | To reinforce the hydroxyethyl cellulose for using it in biomedical and pharmaceutical applications as a drug delivery systems, the grafting of acrylamide onto hydroxyethyl cellulose (AAm-g-HEC) was achieved by Ce(IV) induced free radical polymerization. The AAm-g-HEC was then blended with sodium alginate (NaAlg) to prepare pH-sensitive interpenetrating network (IPN) microspheres (MPs) by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The produced MPs are almost spherical in nature with smooth surfaces. Diclofenac sodium (DS), an anti-inflammatory drug, was successfully encapsulated into the MPs. The % encapsulation efficiency was found to vary between 54 and 67. The MPs were characterized by DSC, SEM and FTIR spectroscopy. In vitro release studies were carried out in simulated gastric fluid of pH 1.2 for 2h followed by simulated intestinal fluid of pH 7.4 at 37°C. The release data have been fitted to an empirical equation to investigate the diffusional exponent (n), which indicated that the release mechanism shifted from anomalous to the super Case-II transport. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 104 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Acrylamide Chemistry Alginates Anti-inflammatory Agents, Non-steroidal Cellulose Analogs & Derivatives Diclofenac Drug Carriers Glucuronic Acid Hexuronic Acids Polymerization Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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