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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mardziah, Radman Ekha Wong, Tin Wui |
| Description | Country affiliation: Malaysia Author Affiliation: Mardziah RE ( Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.) |
| Abstract | CONTEXT: Microspheres prepared from rigid guluronic acid- (MG) and flexible mannuronic acid-rich (MC) alginate will undergo different drug release changes with respect to the influence of microwave on the matrix. An in-depth understanding of their differences in drug release changes is attainable through investigating cross-linking agent-free alginate microspheres prepared by spray-drying technique. OBJECTIVE: The behavior of MG and MC alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated. Sodium diclofenac was used as a model water-soluble drug. The formed microspheres were subjected to drug release, drug content, size, shape, surface morphology, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffractometry analysis. RESULTS: MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MC microspheres resembled MC microspheres. DISCUSSION: The state of polymer-polymer and drug-polymer interaction via O-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres. CONCLUSION: The drug release property of alginate microspheres can be modified by microwave irradiation, and its changes are a function of alginate conformation. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 10 |
| Volume Number | 36 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Alginates Hexuronic Acids Chemistry Microspheres Microwaves Anti-inflammatory Agents, Non-steroidal Pharmacokinetics Diclofenac Drug Carriers Glucuronic Acid Polymers Solubility Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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