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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Hailiang Gao, Tingting Du, Yuzhi Yang, Hongxia Wei, Lixin Bi, Hongtao Ni, Weihua |
| Description | Country affiliation: China Author Affiliation: Wang H ( Department of Neurosurgery, The Second Hospital of Jilin University, Changchun 130033, China.); Gao T ( Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China); Du Y ( Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China); Yang H ( Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China); Wei L ( Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China); Bi H ( Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China); Ni W ( Department of Immunology, College of Basic Medical Science, Jilin University, Changchun 130021, China. Electronic address: 65559211@qq.com.) |
| Abstract | Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a water-soluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1â4)-ß-d-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 131 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Pharmacology Fruit Chemistry Hippophae Immunologic Factors Pectins Animals Body Weight Drug Effects Carbon-13 Magnetic Resonance Spectroscopy Carcinoma, Lewis Lung Pathology Concanavalin A Cytotoxicity, Immunologic Killer Cells, Natural Cytology Lipopolysaccharides Macrophages Male Mice, Inbred C57bl Nitric Oxide Biosynthesis Isolation & Purification Phagocytosis Proton Magnetic Resonance Spectroscopy Spectroscopy, Fourier Transform Infrared T-lymphocytes, Cytotoxic Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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