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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Liqin Xu, Nuo Zhang, Jianjun Zhao, Huajie Lin, Lin Jia, Shouhua Jia, Le |
| Description | Author Affiliation: Wang L ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.); Xu N ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.); Zhang J ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.); Zhao H ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.); Lin L ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.); Jia S ( College of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address: shjia@sdau.edu.cn.); Jia L ( College of Life Science, Shandong Agricultural University, Taian, Shandong 271018, PR China. Electronic address: jiale0525@163.com.) |
| Abstract | Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress. RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average molecular weight), Mn (number-average molecular weight) and Mz (z-average molecular weight) of RPS were 2.86×10(3), 6.85×10(2), and 1.97×10(4)Da, respectively. The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxidant activity. The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury. Results suggest that the RPS might be used as a potential antihyperlipidemic, hepatoprotective and antioxidant product. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 131 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Cordyceps Chemistry Hypolipidemic Agents Pharmacology Liver Drug Effects Polysaccharides Protective Agents Animals Antioxidants Body Weight Chromatography, Gas Lipids Blood Enzymology Pathology Male Malondialdehyde Metabolism Mice Molecular Weight Reference Standards Spectroscopy, Fourier Transform Infrared Superoxide Dismutase Transaminases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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