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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Caccavo, Diego Lamberti, Gaetano Cascone, Sara Barba, Anna Angela Larsson, Anette |
| Description | Country affiliation: Italy Author Affiliation: Caccavo D ( Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.); Lamberti G ( Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy. Electronic address: glamberti@unisa.it.); Cascone S ( Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.); Barba AA ( Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.); Larsson A ( SuMo BIOMATERIALS, A VINNOVA VINN Excellence Center at Chalmers University of Technology, Sweden) |
| Abstract | The bio-adhesion is a complex phenomenon which takes place when two materials (at least one of biological nature, the other usually is a polymeric one) are held together for extended periods of time, usually for local drug delivery purposes. Despite bio-adhesion is widely exploited in commercial pharmaceuticals such as the buccal patches, the underlying phenomena of the process are not completely clarified yet. In this study experimental tests, in which the role of biological membranes is played by a water-rich agarose gel whereas patches are mimicked by hydrogel tablets (made of Carbopol or of Carbopol added with NaCl), have been used to analyze the behavior of the model system above described. Tablets have been forced to adhere on the agarose gel, and after a given contact time they have been detached, recording the required forces. Furthermore weight gain of the tablets (the water transported from the agarose gel toward the tablet) has been quantified. Water transport (during the time in which the contact between tablet and agarose gel is held) and elastic part of mechanical response during the detachment are modelled to achieve a better understanding of the adhesion process. Both the two sub-models nicely reproduce, respectively, the weight gain as well as the swelling of the Carbopol tablets, and the point at which the mechanical response ceases to be purely elastic. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 131 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Carbohydrates Chemistry Elasticity Hydrogel Water Acrylic Resins Adhesiveness Models, Theoretical Molecular Weight Sodium Chloride Tablets Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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