NDLI: Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand

Content Provider	Springer Nature : BioMed Central
Author	Nivesvivat, Thirapa Piyaraj, Phunlerd Thunyaharn, Sudaluck Watanaveeradej, Veerachai Suwanpakdee, Detchvijitr
Abstract	Objective Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is an emerging problem in paediatric populations leading to increased mortality. The purpose of this study was to determine the prevalence, risk factors and clinical outcomes of ESBL-producing Enterobacteriaceae in paediatric blood stream infections (BSIs). A retrospective review of paediatric patients diagnosed with Enterobacteriaceae bacteremia was performed at Phramongkutklao Hospital from 2010 to 2017. Results Among 97 non-duplicated blood isolates, the prevalence of ESBL-producing Enterobacteriaceae was 53.6% (28.9% Escherichia coli and 25.8% Klebsiella spp. isolates). The study indicated that the prevalence of ESBL infection was higher among patients with chronic illness, especially hematologic malignancies, than among patients without underlying disease (P = 0.01). No differences were observed in the prior use of any antibiotics, the use of extended-spectrum cephalosporin, neutropaenia or the presence of an indwelling central venous catheter. Mortality in the ESBL group was significantly higher than that in the non-ESBL group, with observed mortalities of 38.9% and 13.3%, respectively (P < 0.05). In conclusion, BSIs with ESBL-producing Enterobacteriaceae tended to increase infection rates and impact survival rates among paediatric patients.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-018-3729-3.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-018-3729-3
Journal	BMC Research Notes
Issue Number	1
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2018-08-29
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences ESBL-producing Enterobacteriaceae Bacteremia Paediatric Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

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