NDLI: Variability in gut mucosal secretory IgA in mice along a working day

Content Provider	Springer Nature : BioMed Central
Author	Burns, Patricia Oddi, Sofia Forzani, Liliana Tabacman, Eduardo Reinheimer, Jorge Vinderola, Gabriel
Abstract	Objective To assess the variability of secretory immunoglobulin A (S-IgA) in the lumen and feces of mice along a working day. Results Mice were maintained under a 12 h light–dark cycle, light period starting at 8 AM. S-IgA was determined in feces and intestinal content (after one or three washes) at three points along the day: at the beginning, in the middle and at the end of the light period (ELP). Significant reduction in the content of S-IgA in the small intestine fluid and in feces was observed at the end of the light cycle, which coincides with the end of a regular working day (8 PM) in any given animal facility. It was also observed that three washes of the small intestine were more effective than one flush to recover a significant higher amount of S-IgA, with the smallest coefficient of variation observed by the ELP. A smaller CV would imply a reduced number of animals needed to achieve the same meaningful results. The results may be useful when designing animal trials for the selection of probiotic candidates based on their capacity of activating S-IgA, since it would imply a more rational use of experimental animals.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-018-3213-0.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-018-3213-0
Journal	BMC Research Notes
Issue Number	1
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2018-02-05
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences IgA Intestine Circadian rhythm Mice Variability Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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