NDLI: Associations of blood trace elements with bone mineral density: a population-based study in US adults

Content Provider	Springer Nature : BioMed Central
Author	Wu, Chunli Xiao, Yao Jiang, Yuexia
Abstract	Background This study aimed to investigate the association between blood trace elements and bone mineral density (BMD) and to determine the association between blood trace elements and the risk of low BMD/osteoporosis among US adults. Methods We performed a cross-sectional study using data from National Health and Nutrition Examination Survey (NHANES, 2011–2016). Multivariable linear regression models were employed to assess the associations of BMD in lumbar spine (LS-BMD), pelvic (PV-BMD) and total femur (TF-BMD) with blood trace elements, including Fe, Zn, Cu, Se, Mn, Cd, Pb, Hg. Additionally, the associations of low BMD/osteoporosis with blood trace elements were also evaluated using multivariable logistic regression. Results Higher blood Pb levels were found associated with decreased LS-BMD (p for trend < 0.001), PV-BMD (p for trend = 0.007), and TF-BMD (p for trend = 0.003) in female, while higher blood Se levels were associated with increased PV-BMD in female (p for trend = 0.042); no linear association between BMD and other blood trace element was observed. Also, significant associations were found between Pb levels and the prevalence of low BMD (p for trend = 0.030) and the prevalence of osteoporosis (p for trend = 0.036), while association between other blood trace elements and low BMD/osteoporosis was not observed. Conclusion This study provides comprehensive insight into the association between blood trace elements and BMD and supports a detrimental effect of blood Pb levels on bone mass in women. Considering our analysis from a representative US general population, further study is warranted for the extreme levels of blood trace elements on bone metabolism.
Related Links	https://josr-online.biomedcentral.com/counter/pdf/10.1186/s13018-023-04329-9.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13018-023-04329-9
Journal	Journal of Orthopaedic Surgery and Research
Issue Number	1
Volume Number	18
Language	English
Publisher	BioMed Central
Publisher Date	2023-11-03
Access Restriction	Open
Subject Keyword	Orthopedics Surgical Orthopedics Blood trace elements Lead Bone mineral density Osteoporosis
Content Type	Text
Resource Type	Article
Subject	Surgery Orthopedics and Sports Medicine
Journal Impact Factor	2.8/2023
5-Year Journal Impact Factor	3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Associations between apolipoprotein B and bone mineral density: a population-based study

Association between total cholesterol and total bone mineral density in US adults: National Health and Nutrition Examination Survey (NHANES), 2011–2018

Association between muscle strength and mass and bone mineral density in the US general population: data from NHANES 1999–2002

Association of bone mineral density with trichlorophenol: a population-based study

Comparative analysis of bone turnover markers in bone marrow and peripheral blood: implications for osteoporosis

Effect of drugs on bone mineral density in postmenopausal osteoporosis: a Bayesian network meta-analysis

Does clozapine really affect bone mineral density? An experimental study

Associations of blood trace elements with bone mineral density: a population-based study in US adults

Similar Documents

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Associations between apolipoprotein B and bone mineral density: a population-based study

Association between total cholesterol and total bone mineral density in US adults: National Health and Nutrition Examination Survey (NHANES), 2011–2018

Association between muscle strength and mass and bone mineral density in the US general population: data from NHANES 1999–2002

Association of bone mineral density with trichlorophenol: a population-based study

Comparative analysis of bone turnover markers in bone marrow and peripheral blood: implications for osteoporosis

Effect of drugs on bone mineral density in postmenopausal osteoporosis: a Bayesian network meta-analysis

Does clozapine really affect bone mineral density? An experimental study

Associations of blood trace elements with bone mineral density: a population-based study in US adults