NDLI: The effect of caffeic acid on the antinociception and mechanisms in mouse

Content Provider	Springer Nature Link
Author	Sim, Yun Beom Jung, Jun Sub Suh, Hong Won Kim, Seon Mi Lee, Jin Koo Park, Soo Hyun
Copyright Year	2003
Abstract	Antinociceptive profiles of caffeic acid were examined in ICR mice. Caffeic acid administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Moreover, the cumulative response time of nociceptive behaviors induced by an intraplantar formalin injection was reduced by caffeic acid treatment during the 2nd phases. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 μg) or glutamate (20 μg) was diminished by caffeic acid. Intraperitoneal (i.p.) pretreatment with yohimbine (α$_{2}$-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by caffeic acid in the writhing test. However, methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by caffeic acid in the writhing test. Our results suggest that caffeic acid shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of caffeic acid may be mediated by α$_{2}$-adrenergic and opioidergic receptors, but not serotonergic receptor.
Starting Page	177
Ending Page	182
Page Count	6
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	54
Issue Number	2
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	opioid receptor antinociception Applied Microbiology inflammatory pain Biological Techniques caffeic acid Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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