NDLI: Chemical constituents from the sclerotia of Inonotus obliquus

Content Provider	Springer Nature Link
Author	Park, Jinseon Kim, Yu Jin Shim, Sang Hee Min, Byung Sun
Copyright Year	2003
Abstract	Six triterpenoids, two sterols, and two phenolic constituents were isolated from the methanol extract of sclerotia of Inonotus obliquus (Hymenochaetaceae). Their chemical structures were identified as lanosterol (1), 3β-hydroxylanosta-8,24-dien-21-al (3), inotodiol (5), trametenolic acid (6), lanosta-8,25-dien-3,22,24-triol (7), β-sitosterol (2), ergosterolperoxide (4), betulin (8), 2,5-dihydroxy-benzaldehyde (9), and 3,4-dihydroxybenzalacetone (10) on the basis of spectroscopic methods and comparison with the literature. Among these compounds, 9 was isolated for the first time from this mushroom. To the best of our knowledge, the present study marks the first chemical investigation of I. obliquus from Alaska. Among the isolated compounds, compounds 1, 3, 4, 5, 6, 8, 9, and 10 were evaluated for in vitro cytotoxic activity against A 549 (human alveolar basal epithelial carcinoma cells), L1210 (mouse lymphocytic leukemia cells), COLO 205 (colorectal adenocarcinoma cells), MCF-7 (breast cancer cells), and HL-60 (human leukemia) cancer cell lines. 3β-Hydroxylanosta-8,24-dien-21-al (3) and tramentenolic acid (6) exhibited modest cytotoxic effects against L1210 cells with IC$_{50}$s of 62.5 and 34.4 μM, and betulin (8) showed weak cytotoxic effects against A549 and HL-60 with IC$_{50}$s of 81.2 and 87.5 μM, respectively. In addition, 3,4-dihydroxybenzalacetone (10) exhibited the strongest cytotoxic activities against A549 and HL-60 cells with IC$_{50}$ values of 23.6 and 21.7 μM, respectively.
Starting Page	287
Ending Page	294
Page Count	8
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	54
Issue Number	2
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	lanostane-type triterpenoids Inonotus obliquus Applied Microbiology Biological Techniques sterols cytotoxicity Bioorganic Chemistry phenolics
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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