NDLI: Anticomplement activity of compounds isolated from the roots of Euphorbia kansui

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Journal of the Korean Society for Applied Biological Chemistry : Volume 54, Issue 1, February 2011

Journal of the Korean Society for Applied Biological Chemistry : Volume 53

Journal of the Korean Society for Applied Biological Chemistry : Volume 52

Anticomplement activity of compounds isolated from the roots of Euphorbia kansui

Content Provider	Springer Nature Link
Author	Kim, Jung Hee Lee, Hyeong Kyu Li, Gao Shen, Guanghai Lee, Joongku Oh, Sei Ryang
Copyright Year	2003
Abstract	The anticomplement activity-guided fractionation of the methanol extract of Euphorbia kansui L. resulted in isolation of three diterpenes, two triterpenes, and two sterols (1–7) from ethyl acetate fraction. By spectroscopic analysis, their chemical structures were elucidated as: β-amyrin (1); kansuiphorin C (2); 3-O-(2′E,4′Z-decadienoyl)-ingenol (3); 3-O-(2,3-dimethylbutyryl)-13-O-n-dodecanoyl-13-hydroxyingenol (4); β-sitosterol (5); α-euphol (6); β-sitosterol-3-O-β-D-glucopyranoside (7). These compounds were investigated Pitin vitro for their anticomplement activity against the classical pathway of the complement system, with compounds 2–4 exhibiting significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8, 89.5±5.5, and 152.1±6.2 μM.
Starting Page	159
Ending Page	162
Page Count	4
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	54
Issue Number	2
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Euphorbia kansui anticomplement activity 3-O-(2,3-dimethylbutyryl)-13-O-n-dodecanoyl-13-hydroxyingenol Applied Microbiology Biological Techniques kansuiphorin C O-(2′E,4′Z-decadienoyl)-ingenol Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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Anticomplement activity of compounds isolated from the roots of Euphorbia kansui