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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tanji, Noriko Kabir, Faisal Nakamura, Soichiro Katayama, Shigeru |
| Copyright Year | 2014 |
| Abstract | Chlorogenic acid (CGA) is a natural chemical ester composed of caffeic acid and (-)-quinic acid, and is further metabolized into active compounds in the living body. Here, we aimed to provide fundamental information on the antimicrobial action of CGA and related compounds against the Gram-negative bacterium Escherichia coli IFO 3301. Bacteriostatic effects were assessed by spectrophotometry, and bactericidal effects were determined by enumerating viable cells on MacConkey agar plates. CGA and related compounds exhibited specific antimicrobial activity and corresponding reduction in log survival ratio, in which ferulic, isoferulic, benzoic, and hydroxybenzoic acids exhibited obvious antimicrobial activity against E. coli. In a time-kill assay, it was observed that bactericidal effects were associated with treatment time, temperature, and dose. A reduction in log survival ratio was observed at low pH as well as under thermal stress condition. Thus, we demonstrated that CGA and related compounds have not only bacteriostatic effects but also bactericidal effects. |
| Starting Page | 359 |
| Ending Page | 365 |
| Page Count | 7 |
| File Format | |
| ISSN | 17382203 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume Number | 57 |
| Issue Number | 3 |
| e-ISSN | 2234344X |
| Language | English |
| Publisher | The Korean Society for Applied Biological Chemistry |
| Publisher Date | 2014-06-09 |
| Publisher Place | Seoul |
| Access Restriction | Subscribed |
| Subject Keyword | bactericidal effect chlorogenic acid Applied Microbiology Biological Techniques polyphenol bacteriostatic effect Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry, Genetics and Molecular Biology |
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