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| Content Provider | Springer Nature Link |
|---|---|
| Author | Valencia Quintana, Rafael Sánchez Alarcón, Juana Tenorio, María Guadalupe Deng, Youjun Waliszewski, Stefan Marian Valera, Miguel Ángel |
| Copyright Year | 2012 |
| Abstract | The human health impact of AFB$_{1}$ exposure is widespread in developing countries, is known to cause teratogenicity, immunotoxicity, hepatotoxicity and even death in farm animals and humans. As information has accumulated on toxicological effects of AFB$_{1}$, preventive strategies whose objective is to reduce the risks to human health have been implemented. Chemical, physical and biological strategies for the control and prevention of aflatoxicosis and AFB$_{1}$-associated diseases are described. In a primary prevention trial, the purpose is to reduce exposure to AFB$_{1}$ in the diet. In secondary prevention trials, one goal is to modulate the metabolism of ingested AFB$_{1}$ to enhance detoxification processes, thereby reducing internal doses and subsequent risk. This information suggested the probable application of different strategies as an alternative method to avoid the effects produced by the AFB$_{1}$. The extent to which these interventions may ultimately modify the hazard in high-risk populations is an area that needs further investigation. |
| Starting Page | 71 |
| Ending Page | 79 |
| Page Count | 9 |
| File Format | |
| ISSN | 20059752 |
| Journal | Toxicology and Environmental Health Sciences |
| Volume Number | 4 |
| Issue Number | 2 |
| e-ISSN | 22337784 |
| Language | English |
| Publisher | Korean Society of Environmental Risk Assessment and Health Science |
| Publisher Date | 2012-07-07 |
| Publisher Place | Springer |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Aflatoxin B$_{1}$ HCC risks Chemoprevention Aspergillus flavus Chlorophyllin Polyphenols Ethoxyquin Isothiocyanates Enterosorbents DNA damage Environmental Health Pharmacology/Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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