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Aflatoxin Contamination: An Overview on Health Issues, Detection and Management Strategies.
| Content Provider | Europe PMC |
|---|---|
| Author | Alameri, Meera Mohamed Kong, Amanda Shen-Yee Aljaafari, Mariam Nasser Ali, Hajer Al Eid, Khadija Sallagi, Maryam Al Cheng, Wan-Hee Abushelaibi, Aisha Lim, Swee-Hua Erin Loh, Jiun-Yan Lai, Kok-Song |
| Copyright Year | 2023 |
| Abstract | Aflatoxins (AFs) represent one of the main mycotoxins produced by Aspergillus flavus and Aspergillus parasiticus, with the most prevalent and lethal subtypes being AFB1, AFB2, AFG1, and AFG2. AFs are responsible for causing significant public health issues and economic concerns that affect consumers and farmers globally. Chronic exposure to AFs has been linked to liver cancer, oxidative stress, and fetal growth abnormalities among other health-related risks. Although there are various technologies, such as physical, chemical, and biological controls that have been employed to alleviate the toxic effects of AF, there is still no clearly elucidated universal method available to reduce AF levels in food and feed; the only mitigation is early detection of the toxin in the management of AF contamination. Numerous detection methods, including cultures, molecular techniques, immunochemical, electrochemical immunosensor, chromatographic, and spectroscopic means, are used to determine AF contamination in agricultural products. Recent research has shown that incorporating crops with higher resistance, such as sorghum, into animal feed can reduce the risk of AF contamination in milk and cheese. This review provides a current overview of the health-related risks of chronic dietary AF exposure, recent detection techniques, and management strategies to guide future researchers in developing better detection and management strategies for this toxin. |
| Journal | Toxins (Basel) |
| Volume Number | 15 |
| PubMed Central reference number | PMC10140874 |
| Issue Number | 4 |
| PubMed reference number | 37104184 |
| e-ISSN | 20726651 |
| DOI | 10.3390/toxins15040246 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-03-28 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | Aspergillus flavus Aspergillus parasiticus aflatoxin exposure liver cancer oxidative stress hormonal changes food safety |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
