NDLI: Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway

Content Provider	Springer Nature Link
Author	Li, Min Xin, Xiaoyan Wu, Tingting Hua, Teng Wang, Hongbin Wang, Hongbo
Copyright Year	2015
Abstract	Tumor microenvironment participates in the endometrial carcinoma pathogenesis. This study focuses on the interaction between endometrial cancer stromal cells and epithelial cells from normal endometrium tissue using in vitro transwell coculture system and in vivo xenograft model. We demonstrate that cancer interstitial (CI) cells stimulate normal epithelial (NE) cell proliferation. Tumor xenograft model confirmed the pro-proliferative effect of CI cells on epithelial cell growth. Tumor suppressor PTEN was reduced, and oncogene K-ras was increased in epithelial cells cocultured with CI cells. Moreover, we observed increased expression of hepatocyte growth factor (HGF) in CI cells and tumor xenografts derived from the coculturing system. Higher HGF secretion activated Akt signaling pathway, which was reversed by HGF receptor inhibitor (crizotinib). These results demonstrate that endometrial carcinoma stromal cells stimulate epithelial cell proliferation via the HGF/c-Met/Akt signaling pathway.
Starting Page	6239
Ending Page	6248
Page Count	10
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-03-18
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Endometrial carcinoma Tumor microenvironment HGF Akt signaling pathway Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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