NDLI: Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells

Content Provider	Springer Nature Link
Author	Gach, Katarzyna Szymański, Jacek Pomorska, Dorota Długosz, Angelika Modranka, Jakub Janecki, Tomasz Janecka, Anna
Copyright Year	2015
Abstract	The search for novel drug candidates is a priority goal for cancer therapy. Natural products isolated from plants are often used as valuable leads for the synthesis of analogs with simpler structure. Two synthetic α-methylene-δ-lactones with chroman-2-one skeleton, designated DL-3 and DL-5, exhibiting strong cytotoxic activity against several cancer cell lines, have been tested alone and in combination with well-known anticancer drugs, 5-fluorouracil, oxaliplatin, and taxol, in breast cancer MCF-7 cells. Parthenolide, a plant-derived α-methylene-γ-lactone, was used as a positive control. The effects on cell proliferation, DNA damage, and apoptosis induction were evaluated. Neither of the tested compounds significantly enhanced the effects produced by taxol, but a strong synergistic effect was observed with 5-fluorouracil and oxaliplatin. Only small differences between the actions of both α-methylene-δ-lactones were found. The synergistic effects produced by these compounds in MCF-7 cells were stronger as compared with parthenolide. Our findings show that simple and easy-to-obtain synthetic compounds with α-methylene-δ-lactone motif can potentiate the efficiency of anticancer drugs.
Starting Page	5971
Ending Page	5977
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-03-06
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Anticancer drugs Apoptosis Breast cancer Cell proliferation DNA damage α-Methylene-δ-lactones Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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