NDLI: Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells

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Tumor Biology : Volume 37

Tumor Biology : Volume 36

Tumor Biology : Volume 36, Issue 12, December 2015

Tumor Biology : Volume 36, Issue 11, November 2015

Tumor Biology : Volume 36, Issue 10, October 2015

Tumor Biology : Volume 36, Issue 9, September 2015

Tumor Biology : Volume 36, Issue 1, Supplement,September 2015

Tumor Biology : Volume 36, Issue 8, August 2015

Chemokines and their receptors in esophageal cancer—the systematic review and future perspectives

Mitochondrial targeted peptides for cancer therapy

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer

Comments on “In vivo post-contrast 1H-MRS evaluation of malignant and benign breast lesions: a meta-analysis”

Metabolic reprogramming as a continuous changing behavior of tumor cells

Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells

Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population

MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer

Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma

Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small cell lung cancer harbouring KRAS mutation

Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin

Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathway

MicroRNA-335 represents an independent prognostic marker in cervical cancer

Differential expression of the UGT1A family of genes in stomach cancer tissues

Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis

PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma

Androgen receptor promotes esophageal cancer cell migration and proliferation via matrix metalloproteinase 2

Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer

Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro

T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines

Differentially expressed gene profiles of intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and combined hepatocellular-cholangiocarcinoma by integrated microarray analysis

Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression

DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma

Genetic variability of glutathione S-transferases influences treatment outcome of breast cancer

Transcriptome meta-analysis reveals dysregulated pathways in nasopharyngeal carcinoma

CEA serum level as early predictive marker of outcome during EGFR-TKI therapy in advanced NSCLC patients

A link between cold environment and cancer

Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma

Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells

C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn

MiR-124 inhibits cell proliferation in breast cancer through downregulation of CDK4

Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer

Targeting delivery of lipocalin 2-engineered mesenchymal stem cells to colon cancer in order to inhibit liver metastasis in nude mice

Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells

Cannabis smoke can be a major risk factor for early-age laryngeal cancer—a molecular signaling-based approach

Oncolytic adenovirus-mediated short hairpin RNA targeting MYCN gene induces apoptosis by upregulating RKIP in neuroblastoma

The platelet-to-lymphocyte ratio predicts poor survival in patients with huge hepatocellular carcinoma that received transarterial chemoembolization

Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer

Macrophages are needed in the progression of tuberculosis into lung cancer

Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin

Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas

The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia

MicroRNA-191 promotes osteosarcoma cells proliferation by targeting checkpoint kinase 2

Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma

Strong adverse effect of epidermal growth factor receptor 2 overexpression on prognosis of patients with invasive lobular breast cancer: a comparative study with invasive ductal breast cancer in Chinese population

Nuclear shape descriptors by automated morphometry may distinguish aggressive variants of squamous cell carcinoma from relatively benign skin proliferative lesions: a pilot study

The role of tumor suppressor gene SOX11 in prostate cancer

The clinicopathological significance and potential drug target of E-cadherin in NSCLC

Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC

Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells

Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells

Prognostic significance of Ku80 in pT2N0M0 esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy

Prognostic significance of the recurrence pattern and risk factors for recurrence in patients with proximal gastric cancer who underwent curative gastrectomy

MicroRNA-26b inhibits metastasis of osteosarcoma via targeting CTGF and Smad1

Malic enzyme 1 induces epithelial–mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma

Antagomir-1290 suppresses CD133$^{+}$ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase

Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma

Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway

Correlation of microRNA-10b upregulation and poor prognosis in human gliomas

Vascular invasion in hepatitis B virus-related hepatocellular carcinoma with underlying cirrhosis: possible associations with ascites and hepatitis B viral factors?

NFKB1/NFKBIa polymorphisms are associated with the progression of cervical carcinoma in HPV-infected postmenopausal women from rural area

Comparative efficacy of postoperative transarterial chemoembolization with or without antiviral therapy for hepatitis B virus-related hepatocellular carcinoma

A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway

Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway

Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma

RETRACTED ARTICLE: MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma

VEGFA isoforms play a vital role in oral cancer progression

Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients

N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia

Synergistic effect between celecoxib and luteolin is dependent on estrogen receptor in human breast cancer cells

Development of a gLCR-based KRAS mutation detection approach and its comparison with other screening methods

Association of TP53 gene polymorphisms with susceptibility of bladder cancer in Bangladeshi population

Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells

Identification of stage-specific biomarkers in lung adenocarcinoma based on RNA-seq data

Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer

Radical surgery may be not an optimal treatment approach for pulmonary MALT lymphoma

The clinicopathological significance of ALK rearrangements and KRAS and EGFR mutations in primary pulmonary mucinous adenocarcinoma

Vitamin D receptor gene polymorphisms and breast cancer risk among postmenopausal Egyptian women

Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel resistance in human ovarian cancer cells

Clinical significance of serum expression of GROβ in hepatocellular carcinoma

Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population

Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma

Tumor marker analyses in patients with brain metastases: patterns of practice and implications for survival prediction research

Platelet VEGF and serum TGF-β1 levels predict chemotherapy response in non-small cell lung cancer patients

Protein expression and methylation of MGMT, a DNA repair gene and their correlation with clinicopathological parameters in invasive ductal carcinoma of the breast

Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12

Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration

A study on oncogenic role of leptin and leptin receptor in oral squamous cell

Impact of TGF-β1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis

The significant association of CCND1 genotypes with colorectal cancer in Taiwan

Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy

Co-expression of β-arrestin1 and NF-кB is associated with cancer progression and poor prognosis in lung adenocarcinoma

Decreased expression of claudin-3 is associated with a poor prognosis and EMT in completely resected squamous cell lung carcinoma

Adenovirus type 12 E1B 55-kilodalton oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin

Genetic dissimilarity between primary colorectal carcinomas and their lymph node metastases: ploidy, p53, bcl-2, and c-myc expression—a pilot study

Retraction Note to: Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells

Erratum to: CIP2A mediates prostate cancer progression via the c-MYC signaling pathway

Tumor Biology : Volume 36, Issue 7, July 2015

Tumor Biology : Volume 36, Issue 6, June 2015

Tumor Biology : Volume 36, Issue 5, May 2015

Tumor Biology : Volume 36, Issue 4, April 2015

Tumor Biology : Volume 36, Issue 3, March 2015

Tumor Biology : Volume 36, Issue 2, February 2015

Tumor Biology : Volume 36, Issue 1, January 2015

Tumor Biology : Volume 35

Tumor Biology : Volume 34

Tumor Biology : Volume 33

Tumor Biology : Volume 32

Tumor Biology : Volume 31

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells

Content Provider	Springer Nature Link
Author	Pallai, Rajash Bhaskar, Aishwarya Barnett Bernodat, Natalie Gallo Ebert, Christina Pusey, Michelle Nickels, Joseph T. Rice, Lyndi M.
Copyright Year	2015
Abstract	Using yeast two-hybrid analysis, we identified several novel protein interactions for the oncoprotein Cancerous Inhibitor of PP2A (CIP2A) and confirmed a subset of these interactions in human cancer cell lines. Analysis of the interaction in prostate carcinoma cells between CIP2A and leucine-rich repeat-containing protein 59 (LRRC59) suggests that CIP2A is translocated into the nucleus at G2/M through its association with LRRC59. Recent work by others has demonstrated that nuclear CIP2A disrupts mitotic checkpoints, which promotes deregulation of the cell cycle and increases cancerous phenotypes. Thus, we provide a novel therapeutic mechanism for inhibiting CIP2A function in cancerous cells via targeting the CIP2A-LRRC59 interaction.
Starting Page	6383
Ending Page	6390
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-02
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	CIP2A LRRC59 PP2A Prostate cancer Biomarker Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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