NDLI: Chemokines and their receptors in esophageal cancer—the systematic review and future perspectives

Content Provider	Springer Nature Link
Author	Łukaszewicz Zając, Marta Mroczko, Barbara Szmitkowski, Maciej
Copyright Year	2015
Abstract	Esophageal cancer (EC) is an aggressive malignant solid tumor with rapid progression and unfavorable prognosis. The 5-year survival rate for EC patients was estimated to be less than 10 %. Therefore, there is an urgent need to improve diagnostic tool and effective treatment therapies for EC patients. In our paper, the general structure and function of chemokines and their receptors as well as their role in cancer progression were shortly presented. Moreover, the aim of our paper was to summarize and refer the current findings concerning the role of selected chemokines and their receptors as candidates for tumor markers of EC. Some clinical investigations have proved the involvement of these proteins in proliferation, migration, invasiveness and metastasis of tumor cells. Increasing evidence from previous studies suggested that C-X-C motif chemokine 12 (CXCL12), also known as stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 may provide novel diagnostic and prognostic strategies to reduce the burden of EC. Moreover, therapy targeting the CXCL12/CXCR4 axis may open a new direction for treatment of EC patients. However, given their nonspecific nature, the diagnostic value of chemokines and their receptors may be limited. Therefore, future larger investigations, especially in the blood of EC patients, still need to be continued to further clarify the significance of these proteins as potential candidates for tumor markers in diagnosis and prognosis of EC patients.
Starting Page	5707
Ending Page	5714
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-07-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Chemokines Esophageal Tumor Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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