NDLI: Targeting delivery of lipocalin 2-engineered mesenchymal stem cells to colon cancer in order to inhibit liver metastasis in nude mice

Content Provider	Springer Nature Link
Author	Harati, Mozhgan Dehghan Amiri, Fatemeh Jaleh, Fatemeh Mehdipour, Ahmad Harati, Mitra Dehghan Molaee, Sedigheh Bahadori, Marzieh Shokrgozar, Mohammad Ali Jalili, Mohammad Ali Roudkenar, Mehryar Habibi
Copyright Year	2015
Abstract	One of the major obstacles in cancer therapy is the lack of anticancer agent specificity to tumor tissues. The strategy of cell-based therapy is a promising therapeutic option for cancer treatment. The specific tumor-oriented migration of mesenchymal stem cells (MSCs) makes them a useful vehicle to deliver anticancer agents. In this study, we genetically manipulated bone marrow-derived mesenchymal stem cells with their lipocalin 2 (Lcn2) in order to inhibit liver metastasis of colon cancer in nude mice. Lcn2 was successfully overexpressed in transfected MSCs. The PCR results of SRY gene confirmed the presence of MSCs in cancer liver tissue. This study showed that Lcn2-engineered MSCs (MSC-Lcn2) not only inhibited liver metastasis of colon cancer but also downregulated the expression of vascular endothelial growth factor (VEGF) in the liver. Overall, MSCs by innate tropism toward cancer cells can deliver the therapeutic agent, Lcn2, and inhibit cancer metastasis. Hence, it could be a new modality for efficient targeted delivery of anticancer agent to liver metastasis.
Starting Page	6011
Ending Page	6018
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	8
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-03-05
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Mesenchymal stem cells Lipocalin 2 Liver metastasis Nude mice Colon cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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