NDLI: Efficacy and safety of capecitabine as maintenance treatment after first-line chemotherapy using oxaliplatin and capecitabine in advanced gastric adenocarcinoma patients: a prospective observation

Content Provider	Springer Nature Link
Author	Qiu, Miao zhen Wei, Xiao li Zhang, Dong sheng Jin, Ying Zhou, Yi xin Wang, De shen Ren, Chao Bai, Long Luo, Hui yan Wang, Zhi qiang Wang, Feng hua Li, Yu hong Yang, Da jun Xu, Rui hua
Copyright Year	2014
Abstract	The value of maintenance therapy after first-line chemotherapy has been verified in lung cancer and colorectal cancer, however, in gastric cancer, the role of maintenance therapy is still waiting for an answer. The aim of this study is to evaluate the efficacy and safety of capecitabine as maintenance treatment after first-line chemotherapy in advanced gastric adenocarcinoma patients in China. Specimens of patients with advanced gastric adenocarcinoma who were given 6 cycles of oxaliplatin and capecitabine (Xelox for short) as first-line chemotherapy, without disease progression and with grade 2 or higher neuropathy, were collected for analysis. Among them, 64 patients received capecitabine as maintenance (group A) and 222 patients without maintenance as group B. Survival analysis was performed with a Cox regression model. Grades 3–4 adverse events were uncommon; hematologic toxicity was infrequent (5 %) and consistently mild in the phase of maintenance treatment. The median progression-free survival (PFS) was 11.4 months [95 % confidence interval (CI), 10.2–12.6 months] for group A patients, while it was 7.1 months (95 % CI, 6.1–8.0 months) for patients in group B, P < 0.001. The multivariated analysis showed that the maintenance treatment was an independent prognostic factor in advanced gastric adenocarcinoma patients. The style of first-line treatment-maintenance therapy (Xelox-X) was active and feasible for advanced gastric adenocarcinoma patients who had suffered from grade 2 or higher level of neuropathy.
Starting Page	4369
Ending Page	4375
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-02-11
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Advanced gastric adenocarcinoma Capecitabine Maintenance therapy Prognostic factor Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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