NDLI: Expression and clinical significance of BIRC6 in human epithelial ovarian cancer

Content Provider	Springer Nature Link
Author	Wang, Lin Chen, Yan Jie Hou, Jun Wang, Ya Yun Tang, Wen Qing Shen, Xi Zhong Tu, Rui Qin
Copyright Year	2014
Abstract	Baculoviral IAP repeat containing 6 (BIRC6), an unusually large member of the IAP family, may play an important role in oncogenesis. The aim of this study was to assess the value of BIRC6 in predicting tumor recurrence after curative resection in epithelial ovarian cancer (EOC) patients. In this study, the differences of BIRC6 expression in four paired EOC and normal tissue were performed by Western blot, and expression of BIRC6 protein was analyzed in 100 clinicopathologically characterized EOC cases from those who underwent curative resection between 2003 and 2011 by immunohistochemistry. Kaplan-Meier survival estimates and log-rank tests were used to assess the prognostic significance. It was found that BIRC6 expression was higher in the carcinoma tissue than in normal control tissue at protein level by Western blot. There was a significant difference of BIRC6 expression in patients categorized according to tumor differentiation (p = 0.016). Univariate analyses and multivariate analyses revealed that BIRC6 was an independent significant predictor for overall survival and disease-free survival. A prognostic significance of BIRC6 was also found by Kaplan-Meier method. The expression of BIRC6 in the cytoplasm is associated with EOC differentiation and may be a novel predictor for poor prognosis of EOC patients after curative resection.
Starting Page	4891
Ending Page	4896
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-23
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	BIRC6 EOC Prognosis Recurrence Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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