NDLI: Early molecular response in chronic myeloid leukemia patients predicts future response status

Content Provider	Springer Nature Link
Author	Kagita, Sailaja Jiwtani, Sangeeta Uppalapati, Srihari Linga, Vijay Gandhi Gundeti, Sadasivudu Digumarti, Raghunadharao
Copyright Year	2014
Abstract	Imatinib is the frontline therapy for chronic myeloid leukemia (CML) management. Most of the CML patients achieve major responses, but a proportion (nearly 25–35 %) of them develop drug resistance. Molecular monitoring using quantitative real-time PCR at regular intervals according to European LeukemiaNet (ELN) helps in the assessment of long-term outcomes in imatinib-treated CML patients. Eighty-four CML patient samples (42 at diagnosis and 42 at 3-month intervals from the same patients) were analyzed for Bcr-Abl transcript levels. Quantification results revealed that the patients with <10 % Bcr-Abl levels at 3 months had higher rates of complete cytogenetic response (CCyR) and optimal responses compared to patients with >10 % Bcr-Abl levels (P < 0.0001). Patients with >10 % Bcr-Abl levels were found to have 25.0 % of suboptimal response and 3.57 % of failure to imatinib at standard dose. Hence, the present study confirms that early molecular monitoring at 3 months after imatinib initiation helps in predicting the concurrent cytogenetic response and treatment optimization in CML patients.
Starting Page	4443
Ending Page	4446
Page Count	4
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Chronic myeloid leukemia Imatinib Molecular response Bcr-Abl Real-time PCR Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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