NDLI: Clinical significance of RKIP mRNA expression in non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Wang, Qin Wu, Xiaodong Wu, Ting Li, Gui mei Shi, Yi
Copyright Year	2014
Abstract	Raf-1 kinase inhibitor protein (RKIP) expression was associated with the onset, development, invasion, and metastasis of numerous tumor types including prostate cancer, melanoma, colorectal cancer, liver cancer, and breast cancer. However, RKIP mRNA expression and the clinical significance in non-small cell lung cancers (NSCLC) remain unresolved. Real-time PCR was performed to detect the expression of RKIP mRNA in 126 pairs of lung tumor tissues (TT) and surrounding normal tissues (sNT). Correlations between RKIP mRNA expression and clinicopathological features were evaluated by statistical analysis. In the 126 patients examined, RKIP mRNA expression was significantly lower in lung TT than the sNT (p < 0.05). Our results indicated that downregulation of RKIP mRNA expression was associated with a poorer N-stage (p = 0.019) and poorer pathological TNM stage (p = 0.015). However, no significant association was observed between the expression status of RKIP mRNA and clinicopathologic factors, such as gender, age, histological type, and the size of the tumor (p > 0.05). The level of RKIP mRNA expression was found to be significantly downregulated in NSCLC, and the lower mRNA levels correlated with poorer differentiation, advanced pathologic TNM stage in patients with NSCLC.
Starting Page	4377
Ending Page	4380
Page Count	4
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Raf-1 kinase inhibitor protein Real-Time PCR Non-small cell lung cancers Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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