NDLI: Ethnicity modifies the association between functional microRNA polymorphisms and breast cancer risk: a HuGE meta-analysis

Content Provider	Springer Nature Link
Author	Chen, Qiao Hui Wang, Qing Bing Zhang, Bei
Copyright Year	2013
Abstract	Common functional polymorphisms in the promoter region of microRNAs (miRNAs), based on multiple lines of evidence, might participate in transcriptional regulation and other biological processes, which interact to increase the risk of developing breast cancer. Since 2005, many studies have investigated the association between breast cancer risk and common single nucleotide polymorphisms (SNPs) in miRNAs. However, the findings of several meta-analyses are inconclusive or ambiguous. The aim of this Human Genome Epidemiology meta-analysis was to determine more precisely the relationship between common miRNA polymorphisms and breast cancer risk. Twelve case–control studies with a total of 7,170 breast cancer patients and 8,783 healthy controls were included. Eight SNPs in miRNA genes were examined. When all eligible studies were pooled in the meta-analysis, the miR-196a-2 rs11614913T, miR-499 rs3746444T, and miR-605 rs2043556A alleles predicted a decreased risk of breast cancer among Asians, while not Caucasians. In addition, the miR-27a rs895919C allele might be a protective factor for breast cancer among Caucasians. However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model. In conclusion, the current meta-analysis supports that the miR-196a-2 rs11614913T, miR-499 rs3746444T, miR-605 rs2043556A, and miR-27a rs895919C alleles might be protective factors for breast cancer.
Starting Page	529
Ending Page	543
Page Count	15
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	1
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-08-29
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Breast cancer MicroRNA Single nucleotide polymorphism Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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