NDLI: Genetic polymorphisms in XRCC1 gene and susceptibility to glioma in Chinese Han population

Content Provider	Springer Nature Link
Author	Jin, Zheng Xu, Haiyang Zhang, Xianfeng Zhao, Gang
Copyright Year	2013
Abstract	Glioma is the most common type of primary brain malignancy in adults. The X-ray repair cross-complementing group 1 (XRCC1) is an important candidate gene for influencing the pathogenesis of glioma. This study aimed to evaluate the potential association between XRCC1 genetic polymorphisms and glioma susceptibility. This case–control study was conducted in Chinese Han populations consisting of 620 glioma cases and 630 cancer-free controls. XRCC1 genetic polymorphisms were detected by the polymerase chain reaction–restriction fragment length polymorphism and verified using DNA sequencing methods. The c.910A>G and c.1779C>G genetic polymorphisms were identified in this study. Our data suggested that the genotypes/alleles of these two genetic polymorphisms were statistically associated with the increased risk of glioma. As for c.910A>G, the risk of glioma for genotype GG was significantly higher than wild genotype AA (odds ratio (OR) = 1.98, 95 % confidence interval (CI) 1.33–2.94, P = 0.001). As for c.1779C>G, the genotype GG was statistically associated with the increased risk of glioma compared to wild genotype CC (OR = 1.80, 95 % CI 1.17–2.78, P = 0.007). Both of alleles G in c.910A>G and c.1779C>G may contribute to glioma susceptibility (G versus (vs.) A, OR = 1.30, 95 % CI 1.09–1.54, P = 0.003; G vs. C, OR = 1.19, 95 % CI 1.00–1.42, P = 0.045). Our findings indicate that the c.910A>G and c.1779C>G genetic polymorphisms are associated with the susceptibility to glioma in Chinese Han populations and might be used as molecular markers for evaluating glioma risk.
Starting Page	357
Ending Page	362
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	1
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-08-06
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Glioma XRCC1 gene Genetic polymorphisms Risk factors Susceptibility Molecular markers Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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